Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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EAL Putative diguanylate phosphodiesterase

SMART accession number:	SM00052
Description:	Putative diguanylate phosphodiesterase, present in a variety of bacteria.
Interpro abstract (IPR001633):	This domain is found in diverse bacterial signalling proteins. It is called EAL after its conserved residues. The EAL domain is a good candidate for a diguanylate phosphodiesterase function [(PUBMED:11557134)]. The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site. It often but not always occurs along with IPR000014 and IPR000160 domains that are also found in many signalling proteins.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 10877 EAL domains in 10877 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a EAL domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with EAL domain is also avaliable.

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• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 22.22 map02020 Two-component system - General 11.11 map00260 Glycine, serine and threonine metabolism 11.11 map02060 Phosphotransferase system (PTS) 11.11 map00564 Glycerophospholipid metabolism 11.11 map00910 Nitrogen metabolism 11.11 map02030 Bacterial chemotaxis - General 11.11 map00530 Aminosugars metabolism 11.11 map00340 Histidine metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with EAL domain which could be assigned to a KEGG orthologous group, and not all proteins containing EAL domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of EAL domains in PDB

  PDB code	Main view	Title
  2bas		Crystal structure of the bacillus subtilis ykui protein, with an eal domain.
  2r6o		Crystal structure of putative diguanylate cyclase/phosphodiesterase from thiobacillus denitrificans
  2w27		Crystal structure of the bacillus subtilis ykui protein, with an eal domain, in complex with substrate c-di-gmp and calcium
  3gfx		Klebsiella pneumoniae blrp1 ph 4.5 calcium/cy-digmp complex
  3gfy		Klebsiella pneumoniae blrp1 with fmn and cyclic digmp, no metal ions
  3gfz		Klebsiella pneumoniae blrp1 ph 6 manganese/cy-digmp complex
  3gg0		Klebsiella pneumoniae blrp1 ph 9.0 manganese/cy-digmp complex
  3gg1		Klebsiella pneumoniae blrp1 ph 8.0 calcium/cy-digmp complex
  3hv8		Crystal structure of fimx eal domain from pseudomonas aeruginosa bound to c-di-gmp
  3hv9		Crystal structure of fimx eal domain from pseudomonas aeruginosa
  3hvb		Crystal structure of the dual-domain ggdef-eal module of fimx from pseudomonas aeruginosa
  3ii8		Crystal structure of putative diguanylate cyclase/phosphodiesterase complex with cycli di-gmp

• Links (links to other resources describing this domain)

• INTERPRO	IPR001633

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