FCHFes/CIP4 homology domain
|SMART accession number:||SM00055
||Alignment extended from original report. Highly alpha-helical. Also known as the RAEYL motif or the S. pombe Cdc15 N-terminal domain.|
|Interpro abstract (IPR001060):
The FCH domain is a short conserved region of around 60 amino acids first described as a region of homology between FER and CIP4 proteins [(PUBMED:9210375)]. Many proteins containing an FCH domain are involved in the regulation of cytoskeletal rearrangements, vesicular transport and endocytosis. In the CIP4 protein the FCH domain binds to microtubules [(PUBMED:10713100)]. The FCH domain is always found N-terminally and is followed by a coiled-coil region.
Proteins containing an FCH domain can be divided in 3 classes [(PUBMED:11994747)]:
- A subfamily of protein kinases usually associated with an SH2 domain:
- Fps/fes (Fujimani poultry sarcoma/feline sarcoma) proto-oncogenes. They are non-receptor protein-tyrosine kinases preferentially expressed in myeloid lineage. The viral oncogene has an unregulated kinase activity which abrogates the need for cytokines and influences differentiation of haematopoietic progenitor cells.
- Fes related protein (fer). It is an ubiquitously expressed homologue of Fes.
- Adaptor proteins usually associated with a C-terminal SH3 domain:
- Schizosaccharomyces pombe CDC15 protein. It mediates cytoskeletal rearrangements required for cytokinesis. It is essential for viability.
- CD2 cytoplasmic domain binding protein.
- Mammalian Cdc42-interacting protein 4 (CIP4). It may act as a link between Cdc42 signaling and regulation of the actin cytoskeleton.
- Mammalian PACSIN proteins. A family of cytoplasmic phosphoproteins playing a role in vesicle formation and transport.
- A subfamily of Rho-GAP proteins:
- Mammalian RhoGAP4 proteins. They may down-regulate Rho-like GTPases in hematopoietic cells.
- Yeast hypothetical protein YBR260C.
- Caenorhabditis elegans hypothetical protein ZK669.1.
There are 816
FCH domains in 816 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
- Literature (relevant references for this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)