GAL4GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
|SMART accession number:||SM00066|
|Description:||Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.|
|Interpro abstract (IPR001138):|
The N-terminal region of a number of fungal transcriptional regulatory proteins contains a Cys-rich motif that is involved in zinc-dependent binding of DNA. The region forms a binuclear Zn cluster, in which two Zn atoms are bound by six Cys residues [(PUBMED:2107541), (PUBMED:1557122)]. A wide range of proteins are known to contain this domain. These include the proteins involved in arginine, proline, pyrimidine, quinate, maltose and galactose metabolism; amide and GABA catabolism; leucine biosynthesis, amongst others.
|GO process:||regulation of transcription, DNA-dependent (GO:0006355)|
|GO component:||nucleus (GO:0005634)|
|GO function:||sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981), zinc ion binding (GO:0008270)|
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