LIF_OSM

leukemia inhibitory factor
LIF_OSM
SMART accession number:SM00080
Description: OSM, Oncostatin M
Interpro abstract (IPR001581):

On the basis of functional and structural similarities, the small cytokines leukemia inhibitory factor (LIF) and oncostatin (OSM) can be classified into a single family [(PUBMED:1566332), (PUBMED:1717982)].

It has been said [(PUBMED:1717982)] that LIF and OSM can be included in the IL-6 family of cytokines (IPR003573), but while all these cytokines seem to be structurally related, the sequence similarity is not high enough to allow the use of a single consensus pattern.

GO process:immune response (GO:0006955)
GO component:extracellular region (GO:0005576)
GO function:cytokine activity (GO:0005125)
Family alignment:
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There are 28 LIF_OSM domains in 28 proteins in SMART's nrdb database.

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