PA2c

Phospholipase A2
PA2c
SMART accession number:SM00085
Description: -
Interpro abstract (IPR016090):

This entry represents eukaryotic and prokaryotic phospholipase A2 enzymes (PLA2; EC 3.1.1.4), small lipolytic enzymes that releases fatty acids from the second carbon group of glycerol. These enzymes enable the of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides.

The phospholipase domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments [(PUBMED:11897785), (PUBMED:12161451)]. In eukaryotes, PLAS plays a pivotal role in the biosynthesis of prostaglandin and other mediators of inflammation.

Family alignment:
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There are 2287 PA2c domains in 2180 proteins in SMART's nrdb database.

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