RNAse_Pc

Pancreatic ribonuclease
RNAse_Pc
SMART accession number:SM00092
Description:
Interpro abstract (IPR001427): Pancreatic ribonucleases (RNAse) are pyrimidine-specific endonucleases found in high quantity in the pancreas of certain mammals and of some reptiles (PUBMED:3940901). Specifically, the enzymes are involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. Ribonuclease can unwind the DNA helix by complexing with single-stranded DNA; the complex arises by an extended multi-site cation-anion interaction between lysine and arginine residues of the enzyme and phosphate groups of the nucleotides. Other proteins belonging to the pancreatic RNAse family include: bovine seminal vesicle and brain ribonucleases; kidney non-secretory ribonucleases (PUBMED:2734298); liver-type ribonucleases (PUBMED:2611266); angiogenin, which induces vascularisation of normal and malignant tissues; eosinophil cationic protein (PUBMED:2473157), a cytotoxin and helminthotoxin with ribonuclease activity; and frog liver ribonuclease and frog sialic acid-binding lectin. The sequence of pancreatic RNases contains four conserved disulphide bonds and three amino acid residues involved in the catalytic activity.
GO function:pancreatic ribonuclease activity (GO:0004522), nucleic acid binding (GO:0003676)
Family alignment:
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There are 363 RNAse_Pc domains in 363 proteins in SMART's nrdb database.

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