RNAse_PcPancreatic ribonuclease |
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| SMART accession number: | SM00092 |
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| Description: | |
| Interpro abstract (IPR023412): | Pancreatic ribonucleases (RNaseA) are pyrimidine-specific endonucleases found in high quantity in the pancreas of certain mammals and of some reptiles [(PUBMED:3940901)]. Specifically, the enzymes are involved in endonucleolytic cleavage of 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates. Ribonuclease can unwind the DNA helix by complexing with single-stranded DNA; the complex arises by an extended multi-site cation-anion interaction between lysine and arginine residues of the enzyme and phosphate groups of the nucleotides. Other proteins belonging to the pancreatic RNAse family include: bovine seminal vesicle and brain ribonucleases; kidney non-secretory ribonucleases [(PUBMED:2734298)]; liver-type ribonucleases [(PUBMED:2611266)]; angiogenin, which induces vascularisation of normal and malignant tissues; eosinophil cationic protein [(PUBMED:2473157)], a cytotoxin and helminthotoxin with ribonuclease activity; and frog liver ribonuclease and frog sialic acid-binding lectin. The sequence of pancreatic RNases contains four conserved disulphide bonds and three amino acid residues involved in the catalytic activity. |
| Family alignment: |
There are 377 RNAse_Pc domains in 377 proteins in SMART's nrdb database.
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Go to specific node: Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus - Structure (3D structures containing this domain)
3D Structures of RNAse_Pc domains in PDB
PDB code Main view Title 11ba 
Binding of a substrate analogue to a domain swapping protein in the complex of bovine seminal ribonuclease with uridylyl-2',5'-adenosine 11bg 
A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease 1a2w 
Crystal structure of a 3d domain-swapped dimer of bovine pancreatic ribonuclease a 1a4y 
Ribonuclease inhibitor-angiogenin complex 1a5p 
C[40,95]a variant of bovine pancreatic ribonuclease a 1a5q 
P93a variant of bovine pancreatic ribonuclease a 1afk 
Crystal structure of ribonuclease a in complex with 5'- diphosphoadenosine-3'-phosphate 1afl 
Ribonuclease a in complex with 5'-diphosphoadenosine 2'- phosphate at 1.7 angstrom resolution 1afu 
Structure of ribonuclease a at 2.0 angstroms from monoclinic crystals 1agi 
Crystal structure of bovine angiogenin at 1.5 angstroms resolution 1ang 
Crystal structure of human angiogenin reveals the structural basis for its functional divergence from ribonuclease 1aqp 
Ribonuclease a copper complex 1awz 
3d solution structure of human angiogenin determined by 1h, 15n nmr spectroscopy, 30 structures 1b1e 
Crystal structure of human angiogenin variant k40q 1b1i 
Crystal structure of human angiogenin 1b1j 
Crystal structure of human angiogenin variant h13a. 1b6v 
Crystal structure of a hybrid between ribonuclease a and bovine seminal ribonuclease 1bc4 
The solution structure of a cytotoxic ribonuclease from the oocytes of rana catesbeiana (bullfrog), nmr, 15 structures 1bel 
Hydrolase phosphoric diester, rna 1bsr 
Bovine seminal ribonuclease structure at 1.9 angstroms resolution 1bzq 
Complex of a dromedary single-domain vhh antibody fragment with rnase a 1c0b 
Bovine pancreatic ribonuclease a desiccated for 2.5 days 1c0c 
Bovine pancreatic ribonuclease a desiccated for 4.0 days 1c8w 
Thr45gly variant of ribonuclease a 1c9v 
H12a variant of ribonuclease a 1c9x 
H119a variant of ribonuclease a 1cjq 
X-ray crystallographic studies of the denaturation of the denaturation of ribonuclease s. 1cjr 
X-ray crystallographic studies of denaturation in ribonuclease s 1d5d 
The role of phenylalanine 8 in the stabilization of the s protein-s peptide interaction: packing and cavities 1d5e 
The role of phenylalanine 8 in the stabilization of the s protein-s peptide interaction: packing and cavities 1d5h 
Rnase s(f8a). mutant ribonuclease s. 1dfj 
Ribonuclease inhibitor complexed with ribonuclease a 1dy5 
Deamidated derivative of bovine pancreatic ribonuclease 1dyt 
X-ray crystal structure of ecp (rnase 3) at 1.75 a 1dza 
3-d structure of a hp-rnase 1e21 
Ribonuclease 1 des1-7 crystal structure at 1.9a 1eic 
Crystal structure of f120a mutant of bovine pancreatic ribonuclease a 1eid 
Crystal structure of f120g mutant of bovine pancreatic ribonuclease a 1eie 
Crystal structure of f120w mutant of bovine pancreatic ribonuclease a 1eos 
Crystal structure of ribonuclease a complexed with uridylyl(2',5')guanosine (productive binding) 1eow 
Crystal structure of ribonuclease a complexed with uridylyl(2',5')guanosine (non-productive binding) 1f0v 
Crystal structure of an rnase a dimer displaying a new type of 3d domain swapping 1fev 
Crystal structure of the ala4aib mutation in rnase s 1fs3 
Crystal structure of wild-type bovine pancreatic ribonuclease a 1gio 
Nmr solution structure of bovine angiogenin, 10 structures 1gqv 
Atomic resolution (0.98a) structure of eosinophil-derived neurotoxin 1gv7 
Arh-i, an angiogenin/rnase a chimera 1h0d 
Crystal structure of human angiogenin in complex with fab fragment of its monoclonal antibody mab 26-2f 1h1h 
Crystal structure of eosinophil cationic protein in complex with 2',5'-adp at 2.0 a resolution reveals the details of the ribonucleolytic active site 1h52 
Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by x-ray crystallography 1h53 
Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by x-ray crystallography 1h8x 
Domain-swapped dimer of a human pancreatic ribonuclease variant 1hby 
Binding of phosphate and pyrophosphate ions at the active site of human angiogenin as revealed by x-ray crystallography 1hi2 
Eosinophil-derived neurotoxin (edn) - sulphate complex 1hi3 
Eosinophil-derived neurotoxin (edn) - adenosine-2'-5'-diphosphate complex 1hi4 
Eosinophil-derived neurotoxin (edn) - adenosine-3'-5'-diphosphate complex 1hi5 
Eosinophil-derived neurotoxin (edn) - adenosine-5'-diphosphate complex 1izp 
F46l mutant of bovine pancreatic ribonuclease a 1izq 
F46v mutant of bovine pancreatic ribonuclease a 1izr 
F46a mutant of bovine pancreatic ribonuclease a 1j7z 
Osmolyte stabilization of ribonuclease 1j80 
Osmolyte stabilization of rnase 1j81 
Osmolyte stabilization of rnase 1j82 
Osmolyte stabilization of rnase 1jn4 
The crystal structure of ribonuclease a in complex with 2'- deoxyuridine 3'-pyrophosphate (p'-5') adenosine 1js0 
Crystal structure of 3d domain-swapped rnase a minor trimer 1jvt 
Crystal structure of ribonuclease a (ligand-free form) 1jvu 
Crystal structure of ribonuclease a (complexed form) 1jvv 
Crystal structure of ribonuclease a (retro-soaked form) 1k2a 
Modified form of eosinophil-derived neurotoxin 1k58 
Crystal structure of human angiogenin variant d116h 1k59 
Crystal structure of human angiogenin variant q117g 1k5a 
Crystal structure of human angiogenin double variant i119a/f120a 1k5b 
Crystal structure of human angiogenin variant des(121-123) 1kf2 
Atomic resolution structure of rnase a at ph 5.2 1kf3 
Atomic resolution structure of rnase a at ph 5.9 1kf4 
Atomic resolution structure of rnase a at ph 6.3 1kf5 
Atomic resolution structure of rnase a at ph 7.1 1kf7 
Atomic resolution structure of rnase a at ph 8.0 1kf8 
Atomic resolution structure of rnase a at ph 8.8 1kh8 
Structure of a cis-proline (p114) to glycine variant of ribonuclease a 1km8 
The structure of a cytotoxic ribonuclease from the oocyte of rana catesbeiana (bullfrog) 1km9 
The structure of a cytotoxic ribonuclease from the oocyte of rana catesbeiana (bullfrog) 1kvz 
Solution structure of cytotoxic rc-rnase4 1lsq 
Ribonuclease a with asn 67 replaced by a beta-aspartyl residue 1m07 
Residues involved in the catalysis and base specificity of cytotoxic ribonuclease from bullfrog (rana catesbeiana) 1m58 
Solution structure of cytotoxic rc-rnase2 1n0h 
Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorimuron ethyl 1n1x 
Crystal structure analysis of the monomeric [s- carboxyamidomethyl-cys31, s-carboxyamidomethyl-cys32] bovine seminal ribonuclease 1n3z 
Crystal structure of the [s-carboxyamidomethyl-cys31, s- carboxyamidomethyl-cys32] monomeric derivative of the bovine seminal ribonuclease in the liganded state 1o0f 
Rnase a in complex with 3',5'-adp 1o0h 
Ribonuclease a in complex with 5'-adp 1o0m 
Ribonuclease a in complex with uridine-2'-phosphate 1o0n 
Ribonuclease a in complex with uridine-3'-phosphate 1o0o 
Ribonuclease a in complex with adenosine-2',5'-diphosphate 1oj1 
Nonproductive and novel binding modes in cytotoxic ribonucleases from rana catesbeiana of two crystal structures complexed with (2,5 cpg) and d(apcpgpa) 1oj8 
Novel and retro binding modes in cytotoxic ribonucleases from rana catesbeiana of two crystal structures complexed with d(apcpgpa) and (2',5'cpg) 1onc 
The refined 1.7 angstroms x-ray crystallographic structure of p-30, an amphibian ribonuclease with anti-tumor activity 1pu3 
The solution nmr structure and dynamics of a recombinant onconase with altered n-terminal and met23 residues 1qhc 
Crystal structure of ribonuclease a in complex with 5'- phospho-2'-deoxyuridine-3'-pyrophosphate adenosine-3'- phosphate 1qmt 
Recombinant human eosinophil cationic protein 1qwq 
Solution structure of the monomeric n67d mutant of bovine seminal ribonuclease 1r3m 
Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease 1r5c 
X-ray structure of the complex of bovine seminal ribonuclease swapping dimer with d(cpa) 1r5d 
X-ray structure of bovine seminal ribonuclease swapping dimer from a new crystal form 1rar 
Crystal structure of a fluorescent derivative of rnase a 1ras 
Crystal structure of a fluorescent derivative of rnase a 1rat 
Effects of temperature on protein structure and dynamics: x- ray crystallographic studies of the protein ribonuclease-a at nine different temperatures from 98 to 320 k 1rbb 
The crystal structure of ribonuclease b at 2.5-angstroms resolution 1rbc 
Crystallographic structures of ribonuclease s variants with nonpolar substitution at position 13: packing and cavities 1rbd 
Crystallographic structures of ribonuclease s variants with nonpolar substitution at position 13: packing and cavities 1rbe 
Crystallographic structures of ribonuclease s variants with nonpolar substitution at position 13: packing and cavities 1rbf 
Crystallographic structures of ribonuclease s variants with nonpolar substitution at position 13: packing and cavities 1rbg 
Crystallographic structures of ribonuclease s variants with nonpolar substitution at position 13: packing and cavities 1rbh 
Crystallographic structures of ribonuclease s variants with nonpolar substitution at position 13: packing and cavities 1rbi 
Crystallographic structures of ribonuclease s variants with nonpolar substitution at position 13: packing and cavities 1rbj 
Ribonuclease b complex with d(tetra-(deoxy-adenylate)) 1rbn 
The structure of ribonuclease a derivative ii at 2.1 angstroms resolution 1rbw 
Ribonuclease a (e.c.3.1.27.5) with guanidinium 1rbx 
Ribonuclease a (e.c.3.1.27.5) control 1rca 
Structure of the crystalline complex of deoxycytidylyl-3', 5'-guanosine (3',5'-dcpdg) co-crystalised with ribonuclease at 1.9 angstroms resolution. retrobinding in pancreatic rnasea is independent of mode of inhibitor intromission 1rcn 
Crystal structure of the ribonuclease a d(aptpapapg) complex : direct evidence for extended substrate recognition 1rha 
Water dependent domain motion and flexibility in ribonuclease a and the invariant features in its hydration shell. an x-ray study of two low humidity crystal forms of the enzyme 1rhb 
Water dependent domain motion and flexibility in ribonuclease a and the invariant features in its hydration shell. an x-ray study of two low humidity crystal forms of the enzyme 1rnc 
Newly observed binding mode in pancreatic ribonuclease 1rnd 
Newly observed binding mode in pancreatic ribonuclease 1rnf 
X-ray crystal structure of unliganded human ribonuclease 4 1rnm 
Ribonuclease a complex with cytidylic acid (5'cmp) crystallized from 80% ammonium sulphate 1rnn 
Ribonuclease a complex with cytidylic acid (5'cmp) crystallized from 8m sodium formate 1rno 
Ribonuclease a crystallized from 80% ammonium sulphate 1rnq 
Ribonuclease a crystallized from 8m sodium formate 1rnu 
Refinement of the crystal structure of ribonuclease s. comparison with and between the various ribonuclease a structures 1rnv 
Refinement of the crystal structure of ribonuclease s. comparison with and between the various ribonuclease a structures 1rnw 
Recombinant ribonuclease a crystallized from 80% ammonium sulphate 1rnx 
Ribonuclease a crystallized from 3m sodium chloride, 30% ammonium sulfate 1rny 
Ribonuclease a crystallized from 3m cesium chloride, 30% ammonium sulfate 1rnz 
Ribonuclease a crystallized from 2.5m sodium chloride, 3.3m sodium formate 1rob 
Structure of the crystalline complex of cytidylic acid (2'- cmp) with ribonuclease at 1.6 angstroms resolution 1rpf 
The structures of rnase complexed with 3'-cmp and d(cpa): active site conformation and conserved water molecules 1rpg 
Structures of rnase a complexed with 3'-cmp and d(cpa): active site conformation and conserved water molecules 1rph 
Structures of rnase a complexed with 3'-cmp and d(cpa): active site conformation and conserved water molecules 1rra 
Ribonuclease a from rattus norvegicus (common rat) 1rsm 
The 2-angstroms resolution structure of a thermostable ribonuclease a chemically cross-linked between lysine residues 7 and 41 1rta 
Crystal structure disposition of thymidylic acid tetramer in complex with ribonuclease a 1rtb 
Crystal structure disposition of thymidylic acid tetramer in complex with ribonuclease a 1ruv 
Ribonuclease a-uridine vanadate complex: high resolution resolution x-ray structure (1.3 a) 1srn 
The refined crystal structure of a fully active semisynthetic ribonuclease at 1.8 angstroms resolution 1ssa 
A structural investigation of catalytically modified f12ol and f12oy semisynthetic ribonucleases 1ssb 
A structural investigation of catalytically modified f12ol and f12oy semisynthetic ribonucleases 1ssc 
The 1.6 angstroms structure of a semisynthetic ribonuclease crystallized from aqueous ethanol. comparison with crystals from salt solutions and with rnase a from aqueous alcohol solutions 1t9a 
Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, tribenuron methyl 1t9b 
Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron 1t9c 
Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, sulfometuron methyl 1t9d 
Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, metsulfuron methyl 1tq9 
Non-covalent swapped dimer of bovine seminal ribonuclease in complex with 2'-deoxycytidine-2'-deoxyadenosine-3',5'- monophosphate 1u1b 
Structure of bovine pancreatic ribonuclease a in complex with 3'-phosphothymidine (3'-5')-pyrophosphate adenosine 3'-phosphate 1u34 
3d nmr structure of the first extracellular domain of crfr- 2beta, a type b1 g-protein coupled receptor 1un3 
Crystal structure of human angiogenin variant t44d 1un4 
Crystal structure of human angiogenin variant t80a 1un5 
Arh-ii, an angiogenin/rnase a chimera 1w4o 
Binding of nonnatural 3'-nucleotides to ribonuclease a 1w4p 
Binding of nonnatural 3'-nucleotides to ribonuclease a 1w4q 
Binding of nonnatural 3'-nucleotides to ribonuclease a 1wbu 
Fragment based lead discovery using crystallography 1xps 
Bovine ribonuclease a (phosphate-free) (93 % humidity) 1xpt 
Bovine ribonuclease a (phosphate-free) 1y92 
Crystal structure of the p19a/n67d variant of bovine seminal ribonuclease 1y94 
Crystal structure of the g16s/n17t/p19a/s20a/n67d variant of bovine seminal ribonuclease 1ymn 
The study of reductive unfolding pathways of rnase a (y92l mutant) 1ymr 
The study of reductive unfolding pathways of rnase a (y92a mutant) 1ymw 
The study of reductive unfolding pathways of rnase a (y92g mutant) 1yv4 
X-ray structure of m23l onconase at 100k 1yv6 
X-ray structure of m23l onconase at 298k 1yv7 
X-ray structure of (c87s,des103-104) onconase 1z3l 
X-ray crystal structure of a mutant ribonuclease s (f8anb) 1z3m 
Crystal structure of mutant ribonuclease s (f8nva) 1z3p 
X-ray crystal structure of a mutant ribonuclease s (m13nva) 1z5f 
Solution structure of the cytotoxic rc-rnase 3 with a pyroglutamate residue at the n-terminus 1z6d 
Ribonuclease a- imp complex 1z6s 
Ribonuclease a- amp complex 1z7x 
X-ray structure of human ribonuclease inhibitor complexed with ribonuclease i 1z9m 
Crystal structure of nectin-like molecule-1 protein domain 1 2aas 
High-resolution three-dimensional structure of ribonuclease a in solution by nuclear magnetic resonance spectroscopy 2ang 
Crystal structure of human angiogenin of the met(-1) form 2apq 
Crystal structure of an active site mutant of bovine pancreatic ribonuclease a (h119a-rnase a) with a 10- glutamine expansion in the c-terminal hinge-loop. 2bex 
Crystal structure of placental ribonuclease inhibitor in complex with human eosinophil derived neurotoxin at 2a resolution 2blp 
Rnase before unattenuated x-ray burn 2blz 
Rnase after a high dose x-ray "burn" 2bwk 
Murine angiogenin, sulphate complex 2bwl 
Murine angiogenin, phosphate complex 2bzz 
Crystal structures of eosinophil-derived neurotoxin in complex with the inhibitors 5'-atp, ap3a, ap4a and ap5a 2c01 
Crystal structures of eosinophil-derived neurotoxin in complex with the inhibitors 5'-atp, ap3a, ap4a and ap5a 2c02 
Crystal structures of eosinophil-derived neurotoxin in complex with the inhibitors 5'-atp, ap3a, ap4a and ap5a 2c05 
Crystal structures of eosinophil-derived neurotoxin in complex with the inhibitors 5'-atp, ap3a, ap4a and ap5a 2e0j 
Mutant human ribonuclease 1 (r31l, r32l) 2e0l 
Mutant human ribonuclease 1 (q28l, r31l, r32l) 2e0m 
Mutant human ribonuclease 1 (t24l, q28l, r31l, r32l) 2e0o 
Mutant human ribonuclease 1 (v52l, d53l, n56l, f59l) 2e33 
Structural basis for selection of glycosylated substrate by scffbs1 ubiquitin ligase 2e3w 
X-ray structure of native rnase a 2g4w 
Anomalous substructure of ribonuclease a (c2) 2g4x 
Anomalous substructure od ribonuclease a (p3221) 2g8q 
The crystal structure of rnase a from monoclinic crystals at 100 k 2g8r 
The crystal structure of the rnase a- 3-n-piperidine-4- carboxyl-3-deoxy-ara-uridine complex 2gmk 
Crystal structure of onconase double mutant with spontaneously-assembled (amp) 4 stack 2hky 
Nmr solution structure of human rnase 7 2i5s 
Crystal structure of onconase with bound nucleic acid 2j4t 
Biological and structural features of murine angiogenin-4, an angiogenic protein 2jnc 
Refined 3d nmr structure of ecd1 of mcrf-r2beta at ph 5 2jnd 
3d nmr structure of ecd1 of mcrf-r2b in complex with astressin 2k11 
Solution structure of human pancreatic ribonuclease 2kb5 
Solution nmr structure of eosinophil cationic protein/rnase 2kb6 
Solution structure of onconase c87a/c104a 2nui 
X-ray structure of synthetic [d83a]rnase a 2op2 
Crystal structure of rnase double-mutant v43c r85c with extra disulphide bond 2oqf 
Structure of a synthetic, non-natural analogue of rnase a: [n71k(ade), d83a]rnase a 2p42 
Complex of a camelid single-domain vhh antibody fragment with rnase a at 1.8a resolution: se3-mono-2 crystal form with three se-met sites (m34, m51, m83) in vhh scaffold 2p43 
Complex of a camelid single-domain vhh antibody fragment with rnase a at 1.65a resolution: se3-mono-1 crystal form with three se-met sites (m34, m51, m83) in vhh scaffold 2p44 
Complex of a camelid single-domain vhh antibody fragment with rnase a at 1.8a resolution: se5a-mono-1 crystal form with five se-met sites (m34, m51, f68m, m83, l86m) in vhh scaffold 2p45 
Complex of a camelid single-domain vhh antibody fragment with rnase a at 1.1a resolution: se5b-ortho-1 crystal form with five se-met sites (l4m, m34, m51, f68m, m83) in vhh scaffold. 2p46 
Complex of a camelid single-domain vhh antibody fragment with rnase a at 2.5a resolution: se5b-ortho-2 crystal form with five se-met sites (l4m, m34, m51, f68m, m83) in vhh scaffold. 2p47 
Complex of a camelid single-domain vhh antibody fragment with rnase a at 2.5a resolution: se5b-tri crystal form with five se-met sites (l4m, m34, m51, f68m, m83) in vhh scaffold. 2p48 
Complex of a camelid single-domain vhh antibody fragment with rnase a at 2.3a resolution: se5b-tetra crystal form with five se-met sites (l4m, m34, m51, f68m, m83) in vhh scaffold. 2p49 
Complex of a camelid single-domain vhh antibody fragment with rnase a at 1.4a resolution: native mono_1 crystal form 2p4a 
X-ray structure of a camelid affinity matured single-domain vhh antibody fragment in complex with rnase a 2p6z 
Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from rana pipiens oocytes 2p7s 
Enzymatic and structural characterisation of amphinase, a novel cytotoxic ribonuclease from rana pipiens oocytes 2q4g 
Ensemble refinement of the protein crystal structure of human ribonuclease inhibitor complexed with ribonuclease i 2qca 
A new crystal form of bovine pancreatic rnase a in complex with 2'-deoxyguanosine-5'-monophosphate 2rat 
Effects of temperature on protein structure and dynamics: x- ray crystallographic studies of the protein ribonuclease-a at nine different temperatures from 98 to 320 k 2rln 
Thermodynamic and structural consequences of changing a sulphur atom to a methylene group in the m13nle mutation in ribonuclease s 2rnf 
X-ray crystal structure of human ribonuclease 4 in complex with d(up) 2rns 
Refinement of the crystal structure of ribonuclease s. comparison with and between the various ribonuclease a structures 2vq8 
Rnase zf-1a 2vq9 
Rnase zf-3e 2w5g 
Rnase a-5'-atp complex 2w5i 
Rnase a-ap3a complex 2w5k 
Rnase a-nadph complex 2w5l 
Rnase a-nadp complex 2w5m 
Rnase a-pyrophosphate ion complex 2zmc 
Crystal structure of human mitotic checkpoint kinase mps1 catalytic domain apo form 2zmd 
Crystal structure of human mps1 catalytic domain t686a mutant in complex with sp600125 inhibitor 2zpo 
Crystal structure of green turtle egg white ribonuclease 3a1r 
Neutron crystal structure analysis of bovine pancreatic ribonuclease a 3bcm 
Crystal structure of the unswapped form of p19a/l28q/n67d bs-rnase 3bco 
Crystal structure of the swapped form of p19a/l28q/n67d bs- rnase 3bcp 
Crystal structure of the swapped non covalent form of p19a/l28q/n67d bs-rnase 3d6o 
The rnase a- 5'-deoxy-5'-n-(ethyl isonipecotatyl)uridine complex 3d6p 
Rnase a- 5'-deoxy-5'-n-morpholinouridine complex 3d6q 
The rnase a- 5'-deoxy-5'-n-piperidinouridine complex 3d7b 
The ribonuclease a- 5'-deoxy-5'-n-pyrrolidinouridine complex 3d8y 
Rnase a- 5'-deoxy-5'-n-piperidinothymidine complex 3d8z 
Rnase a- 5'-deoxy-5'-n-pyrrolidinothymidine complex 3dh5 
Crystal structure of bovine pancreatic ribonuclease a (wild- type) 3dh6 
Crystal structure of bovine pancreatic ribonuclease a variant (v47a) 3di7 
Crystal structure of bovine pancreatic ribonuclease a variant (v54a) 3di8 
Crystal structure of bovine pancreatic ribonuclease a variant (v57a) 3di9 
Crystal structure of bovine pancreatic ribonuclease a variant (i81a) 3dib 
Crystal structure of bovine pancreatic ribonuclease a variant (i106a) 3dic 
Crystal structure of bovine pancreatic ribonuclease a variant (v108a) 3djo 
Bovine seminal ribonuclease uridine 2' phosphate complex 3djp 
Bovine seminal ribonuclease- uridine 3' phosphate complex 3djq 
Bovine seminal ribonuclease- uridine 5' diphosphate complex 3djv 
Bovine seminal ribonuclease- cytidine 3' phosphate complex 3djx 
Bovine seminal ribonuclease- cytidine 5' phosphate complex 3dxg 
Ribonuclease a- uridine 5' phosphate complex 3dxh 
Ribonuclease a uridine 5' diphosphate complex 3eux 
Crystal structure of crosslinked ribonuclease a 3euy 
Crystal structure of ribonuclease a in 50% dioxane 3euz 
Crystal structure of ribonuclease a in 50% dimethylformamide 3ev0 
Crystal structure of ribonuclease a in 70% dimethyl sulfoxide 3ev1 
Crystal structure of ribonuclease a in 70% hexanediol 3ev2 
Crystal structure of ribonuclease a in 70% isopropanol 3ev3 
Crystal structure of ribonuclease a in 70% t-butanol 3ev4 
Crystal structure of ribonuclease a in 50% trifluoroethanol 3ev5 
Crystal structure of ribonuclease a in 1m trimethylamine n- oxide 3ev6 
Crystal structure of ribonuclease a in 50% r,s,r-bisfuranol 3f8g 
The x-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities 3fkz 
X-ray structure of the non covalent swapped form of the s16g/t17n/a19p/a20s/k31c/s32c mutant of bovine pancreatic ribonuclease 3fl0 
X-ray structure of the non covalent swapped form of the q28l/k31c/s32c mutant of bovine pancreatic ribonuclease in complex with 2'-deoxycytidine-2'-deoxyguanosine-3',5'- monophosphate 3fl1 
X-ray structure of the non covalent swapped form of the a19p/q28l/k31c/s32c mutant of bovine pancreatic ribonuclease in complex with 2'-deoxycytidine-2'- deoxyguanosine-3',5'-monophosphate 3fl3 
X-ray structure of the ligand free non covalent swapped form of the a19p/q28l/k31c/s32c mutant of bovine pancreatic ribonuclease 3i7w 
High pressure structure of wild-type rnase a (0.67 gpa) 3i7x 
High pressure structure of i106a rnase a variant (0.35 gpa) 3i7y 
High pressure structure of i106a variant of rnase a (0.48 gpa) 3jw1 
Crystal structure of bovine pancreatic ribonuclease complexed with uridine-5'-monophosphate at 1.60 a resolution 3kcc 
Crystal structure of d138l mutant of catabolite gene activator protein 3rat 
Effects of temperature on protein structure and dynamics: x- ray crystallographic studies of the protein ribonuclease-a at nine different temperatures from 98 to 320 k 3rn3 
Segmented anisotropic refinement of bovine ribonuclease a by the application of the rigid-body tls model 3rsd 
Structure of the d121n variant of ribonuclease a 3rsk 
Structure of the k7a/r10a/k66a variant of ribonuclease a 3rsp 
Structure of the p93g variant of ribonuclease a 3srn 
Structural changes that accompany the reduced catalytic efficiency of two semisynthetic ribonuclease analogs 4rat 
Effects of temperature on protein structure and dynamics: x- ray crystallographic studies of the protein ribonuclease-a at nine different temperatures from 98 to 320 k 4rsd 
Structure of the d121a variant of ribonuclease a 4rsk 
Structure of the k7a/r10a/k66a variant of ribonuclease a complexed with 3'-ump 4srn 
Structural changes that accompany the reduced catalytic efficiency of two semisynthetic ribonuclease analogs 5rat 
Effects of temperature on protein structure and dynamics: x- ray crystallographic studies of the protein ribonuclease-a at nine different temperatures from 98 to 320 k 5rsa 
Comparison of two independently refined models of ribonuclease-a 6rat 
Effects of temperature on protein structure and dynamics: x- ray crystallographic studies of the protein ribonuclease-a at nine different temperatures from 98 to 320 k 6rsa 
Nuclear magnetic resonance and neutron diffraction studies of the complex of ribonuclease*a with uridine vanadate, a transition-state analogue 7rat 
Effects of temperature on protein structure and dynamics: x- ray crystallographic studies of the protein ribonuclease-a at nine different temperatures from 98 to 320 k 7rsa 
Structure of phosphate-free ribonuclease a refined at 1.26 angstroms 8rat 
Effects of temperature on protein structure and dynamics: x- ray crystallographic studies of the protein ribonuclease-a at nine different temperatures from 98 to 320 k 8rsa 
Crystal structure of two covalent nucleoside derivatives of ribonuclease a 9rat 
Effects of temperature on protein structure and dynamics: x- ray crystallographic studies of the protein ribonuclease-a at nine different temperatures from 98 to 320 k 9rsa 
Crystal structure of two covalent nucleoside derivatives of ribonuclease a - Links (links to other resources describing this domain)
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INTERPRO IPR023412 PROSITE PS00127