|SMART accession number:||SM00099
||The tob/btg1 is a family of proteins that inhibit cell proliferation. |
|Interpro abstract (IPR002087):
||Anti-proliferative proteins have been shown to include mammalian and avian protein BTG1 (which appears to be involved in negative regulation of cell proliferation) and rat/mouse NGF-inducible protein PC3/TIS21 (BTG2) [(PUBMED:1373383), (PUBMED:8325512), (PUBMED:1849653)]. These proteins have from 158 to 363 amino acid residues, that are highly similar and include 3 conserved cysteine residues. BTG2 seems to have a signal sequence; while the other proteins may lack such a domain. The sequence of the N-terminal half of these proteins is well conserved.
There are 586 btg1 domains in 474 proteins in SMART's nrdb database.
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- Evolution (species in which this domain is found)
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- Structure (3D structures containing this domain)
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