Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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btg1 tob/btg1 family

SMART accession number:	SM00099
Description:	The tob/btg1 is a family of proteins that inhibit cell proliferation.
Interpro abstract (IPR002087):	Anti-proliferative proteins have been shown to include mammalian and avian protein BTG1 (which appears to be involved in negative regulation of cell proliferation) and rat/mouse NGF-inducible protein PC3/TIS21 (BTG2) [(PUBMED:1373383), (PUBMED:8325512), (PUBMED:1849653)]. These proteins have from 158 to 363 amino acid residues, that are highly similar and include 3 conserved cysteine residues. BTG2 seems to have a signal sequence; while the other proteins may lack such a domain. The sequence of the N-terminal half of these proteins is well conserved.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 143 btg1 domains in 143 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a btg1 domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with btg1 domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Rouault JP et al.
  • BTG1, a member of a new family of antiproliferative genes.
  • EMBO J. 1992; 11: 1663-70
  • Display abstract

  • The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. We report here the cloning and sequencing of the human BTG1 cDNA and establish the genomic organization of this gene. The full-length cDNA isolated from a lymphoblastoid cell line contains an open reading frame of 171 amino acids. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and is down-regulated when cells progress throughout G1. Furthermore, transfection experiments of NIH3T3 cells indicate that BTG1 negatively regulates cell proliferation. The BTG1 open reading frame is 60% homologous to PC3, an immediate early gene induced by nerve growth factor in rat PC12 cells. Sequence and Northern blot analyses indicate that BTG1 and PC3 are not cognate genes. We then postulate that these two genes are the first members of a new family of antiproliferative genes.

• Structure (3D structures containing this domain)

• 3D Structures of btg1 domains in PDB

  PDB code	Main view	Title
  2d5r		Crystal structure of a tob-hcaf1 complex
  2z15		Crystal structure of human tob1 protein
  3djn		Crystal structure of mouse tis21
  3dju		Crystal structure of human btg2
  3e9v		Crystal structure of human b-cell translocation gene 2 (btg2)

• Links (links to other resources describing this domain)

• BLOCKS	BTG1_1
  PFAM	Anti_proliferat
  INTERPRO	IPR002087
  PROSITE	BTG1_1

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