B_lectin

Bulb-type mannose-specific lectin
B_lectin
SMART accession number:SM00108
Description:
Interpro abstract (IPR001480):

A bulb lectin super-family (Amaryllidaceae, Orchidaceae and Aliaceae) contains a ~115-residue-long domain whose overall three dimensional fold is very similar to that of [(PUBMED:9132060), (PUBMED:7664110)]:

  • Dictyostelium discoideum comitin, an actin binding protein
  • Curculigo latifolia curculin, a sweet tasting and taste-modifying protein

This domain generally binds mannose, but in at least one protein, curculin, it is apparently devoid of mannose-binding activity.

Each bulb-type lectin domain consists of three sequential beta-sheet subdomains (I, II, III) that are inter-related by pseudo three-fold symmetry. The three subdomains are flat four-stranded, antiparrallel beta-sheets. Together they form a 12-stranded beta-barrel in which the barrel axis coincides with the pseudo 3-fold axis.

Family alignment:
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There are 1587 B_lectin domains in 1483 proteins in SMART's nrdb database.

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