HECTcDomain Homologous to E6-AP Carboxyl Terminus with
|SMART accession number:||SM00119|
|Description:||E3 ubiquitin-protein ligases. Can bind to E2 enzymes.|
|Interpro abstract (IPR000569):|
The name HECT comes from 'Homologous to the E6-AP Carboxyl Terminus' [(PUBMED:7708685)]. Proteins containing this domain at the C terminus include ubiquitin-protein ligase, which regulates ubiquitination of CDC25. Ubiquitin-protein ligase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates. A cysteine residue is required for ubiquitin-thiolester formation. Human thyroid receptor interacting protein 12, which also contains this domain, is a component of an ATP-dependent multisubunit protein that interacts with the ligand binding domain of the thyroid hormone receptor. It could be an E3 ubiquitin-protein ligase. Human ubiquitin-protein ligase E3A interacts with the E6 protein of the cancer-associated Human papillomavirus type 16 and Human papillomavirus type 18. The E6/E6-AP complex binds to and targets the P53 tumour-suppressor protein for ubiquitin-mediated proteolysis.
|GO process:||cellular protein modification process (GO:0006464)|
|GO component:||intracellular (GO:0005622)|
|GO function:||ubiquitin-protein ligase activity (GO:0004842)|
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