PI3K_p85B

PI3-kinase family, p85-binding domain
PI3K_p85B
SMART accession number:SM00143
Description: Region of p110 PI3K that binds the p85 subunit.
Interpro abstract (IPR003113):

Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that phosphorylate 4,5-bisphonate (PI(4,5) P2 or PIP2) at the 3-position of the inositol ring, and thus generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which, in turns, initiates a vast array of signaling events. PI3Ks can be grouped into three classes based on their domain organisation. Class I PI3Ks are heterodimers consisting of a p110 catalytic subunit and a regulatory subunit of either the p85 type (associated with the class IA p110 isoforms p110alpha, p110beta or p110delta) or the p101 type (associated with the class IB p110 isoform p110gamma). Common to all catalytic subunits are an N-terminal adaptor-binding domain (ABD) that binds to p85, a Ras-binding domain (RBD), a putative membrane-binding domain (C2), a helical domain of unknown function, and a kinase catalytic domain [(PUBMED:17626883), (PUBMED:18079394), (PUBMED:20081827)].

PI3K ABD is a small globular domain of about 100 residues in length with an alpha/beta-sandwich topology [(PUBMED:17626883), (PUBMED:18079394), (PUBMED:20081827)].

Family alignment:
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There are 336 PI3K_p85B domains in 322 proteins in SMART's nrdb database.

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