NAT_PEP

Natriuretic peptide
NAT_PEP
SMART accession number:SM00183
Description: Atrial natriuretic peptides are vertebrate hormones important in the overall control of cardiovascular homeostasis and sodium and water balance in general.
Interpro abstract (IPR000663): Atrial natriuretic peptides (ANPs) are vertebrate hormones that play an important role in the control of cardiovascular homeostatis, and sodium and water balance in general [(PUBMED:1652921), (PUBMED:2536732), ]. There are different NPs that vary in length but share a common core. All are processed from a single precursor. A disulphide bond resident in the C-terminal section is required for full activity of atriopeptins. The family of NPs includes structurally-related peptides that elicit similar pharmacological spectra. Amongst these are brain natriuretic peptide (BNP); C-type natriuretic peptide (CNP); ventricular natriuretic peptide (VNP) [(PUBMED:1828035)]; and green mamba natriuretic peptide (DNP) [(PUBMED:1352773)].
GO component:extracellular region (GO:0005576)
GO function:hormone activity (GO:0005179)
Family alignment:
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There are 245 NAT_PEP domains in 216 proteins in SMART's nrdb database.

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