SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains.
SMART accession number:SM00198
Description: Human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein represent functional links between plant defense systems and human immune system. This family has no known function.
Interpro abstract (IPR001283):

The cysteine-rich secretory proteins (Crisp) are predominantly found in the mammalian male reproductive tract as well as in the venom of reptiles. This family includes mammalian testis-specific protein (Tpx-1), also known as cysteine-rich secretory protein 2 (CRISP2) [(PUBMED:2613236)]; venom allergen 5 from vespid wasps and venom allergen 3 from fire ants, which are potent allergens that mediate allergic reactions to stings insects of the Hymenoptera family [(PUBMED:8454859)]; plant pathogenesis proteins of the PR-1 family [(PUBMED:2026137)], which are synthesised during pathogen infection or other stress-related responses; allurin, a sperm chemoattractant [(PUBMED:18342304)], serotriflin [(PUBMED:18222185)], etc.

The precise function of some of these proteins is still unclear. Tpx-1 or CRISP2 may regulate some ion channels' activity and thereby regulate calcium fluxes during sperm capacitation [(PUBMED:16339766)].

Family alignment:
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There are 4837 SCP domains in 4661 proteins in SMART's nrdb database.

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