Domain found in sea urchin sperm protein, enterokinase, agrin
SMART accession number:SM00200
Description: Proposed function of regulating or binding carbohydrate sidechains.
Interpro abstract (IPR000082): SEA is an extracellular domain associated with O-glycosylation [(PUBMED:7670383)]. Proteins found to contain SEA-modules include, agrin, enterokinase, 63 kDa Strongylocentrotus purpuratus (Purple sea urchin) sperm protein, perlecan (heparan sulphate proteoglycan core, mucin 1 and the cell surface antigen, 114/A10, and two functionally uncharacterised, probably extracellular, Caenorhabditis elegans proteins. Despite the functional diversity of these adhesive proteins, a common denominator seems to be their existence in heavily glycosylated environments. In addition, the better characterised proteins all contain O-glycosidic-linked carbohydrates such as heparan sulphate that contribute considerably to their molecular masses. The common module might regulate or assist binding to neighbouring carbohydrate moieties.

Enterokinase, the initiator of intestinal digestion, is a mosaic protease composed of a distinctive assortment of domains [(PUBMED:8052624)].

Family alignment:
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There are 572 SEA domains in 438 proteins in SMART's nrdb database.

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