FHAForkhead associated domain
|SMART accession number:||SM00240|
|Description:||Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.|
|Interpro abstract (IPR000253):|
The forkhead-associated (FHA) domain [(PUBMED:7482699)] is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognise phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded beta sandwich, which sometimes contain small helical insertions between the loops connecting the strands [(PUBMED:11911881)].
To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not archaeal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes - DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples.
|GO function:||protein binding (GO:0005515)|
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