SAM / Pointed domain
SMART accession number:SM00251
Description: A subfamily of the SAM domain
Interpro abstract (IPR003118):

Transcription factors are protein molecules that bind to specific DNA sequences in the genome, resulting in the induction or inhibition of gene transcription [(PUBMED:2163347)]. The ets oncogene is such a factor, possessing a region of 85-90 amino acids known as the ETS (erythroblast transformation specific) domain [(PUBMED:2163347), (PUBMED:2253872)]. This domain is rich in positively-charged and aromatic residues, and binds to purine-rich segments of DNA. The ETS domain IPR000418 has been identified in other transcription factors such as PU.1, human erg, human elf-1, human elk-1, GA binding protein, and a number of others [(PUBMED:2163347), (PUBMED:2253872), (PUBMED:8425553)]. It is generally localized at the C terminus of the protein, with the exception of ELF-1, ELK-1, ELK-3, ELK-4 and ERF where it is found at the N terminus.

This entry describes the highly conserved PNT (or Pointed) domain which is found within a subset of the ETs domain (IPR000418 ), including mammalian Ets-1, Ets-2, Erg, Fli-1, GABPalpha, and Tel, as well as Drosophila Pnt-P2 and Yan. The PNT domain (IPR001660 ) through a common tertiary arrangement of four alpha-helices. A role in protein-protein association has been established for the PNT domain [(PUBMED:10828014), (PUBMED:15351649)].

GO component:nucleus (GO:0005634)
GO function:sequence-specific DNA binding (GO:0043565)
Family alignment:
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There are 560 SAM_PNT domains in 559 proteins in SMART's nrdb database.

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