Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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LysM Lysin motif

SMART accession number:	SM00257
Description:
Interpro abstract (IPR002482):	This domain is about 40 residues long and is found in a variety of enzymes involved in bacterial cell wall degradation [(PUBMED:1352512)]. This domain may have a general peptidoglycan binding function.
GO process:	cell wall macromolecule catabolic process (GO:0016998)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 10371 LysM domains in 6829 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a LysM domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with LysM domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 50.00 map00550 Peptidoglycan biosynthesis 27.85 map00530 Aminosugars metabolism 4.43 map00240 Pyrimidine metabolism 4.43 map00230 Purine metabolism 3.16 map00760 Nicotinate and nicotinamide metabolism 2.53 map00780 Biotin metabolism 2.53 map00310 Lysine degradation 2.53 map02010 ABC transporters - General 0.63 map00511 N-Glycan degradation 0.63 map00562 Inositol phosphate metabolism 0.63 map00632 Benzoate degradation via CoA ligation 0.63 map01032 Glycan structures - degradation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with LysM domain which could be assigned to a KEGG orthologous group, and not all proteins containing LysM domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of LysM domains in PDB

  PDB code	Main view	Title
  1e0g		Lysm domain from e.coli mltd
  1y7m		Crystal structure of the b. subtilis ykud protein at 2 a resolution
  2djp		The solution structure of the lysm domain of human hypothetical protein sb145

• Links (links to other resources describing this domain)

• INTERPRO	IPR002482

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