Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

• HOME
• SETUP
• FAQ
• ABOUT
• GLOSSARY
• WHAT'S NEW
• FEEDBACK

FOLN Follistatin-N-terminal domain-like

SMART accession number:	SM00274
Description:	Follistatin-N-terminal domain-like, EGF-like. Region distinct from the kazal-like sequence
Interpro abstract (IPR003645):	This EGF-like domain resembles the follistatin-N-terminal domain, and is distinct from the kazal-like sequence. Follistatin binds to activin and is a specific inhibotor of the biosynthesis and secretion of pituitary follicle stimulating hormone. This domain is also found in prespore vesicle protein and agrin.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 45690 FOLN domains in 5924 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing FOLN domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with FOLN domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing FOLN domain in the selected taxonomic class.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 38.71 map04360 Axon guidance 25.81 map04512 ECM-receptor interaction 25.81 map04350 TGF-beta signaling pathway 3.23 map05010 Alzheimer's disease 3.23 map04320 Dorso-ventral axis formation 3.23 map04330 Notch signaling pathway This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with FOLN domain which could be assigned to a KEGG orthologous group, and not all proteins containing FOLN domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of FOLN domains in PDB

  PDB code	Main view	Title
  1bmo		BM-40, FS/EC DOMAIN PAIR
  1lr7		Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue sucrose octasulphate (SOS)
  1lr8		Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)
  1lr9		STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN
  1nub		HELIX C DELETION MUTANT OF BM-40 FS-EC DOMAIN PAIR
  2arp		Activin A in complex with Fs12 fragment of follistatin
  2b0u		The Structure of the Follistatin:Activin Complex
  2kcx		Solution NMR Structure of Kazal-1 Domain of Human Follistatin-related protein 3 (FSTL-3). Northeast Structural Genomics Target HR6186A.
  2p6a		The structure of the Activin:Follistatin 315 complex
  2v53		Crystal structure of a SPARC-collagen complex
  3b4v		X-Ray structure of Activin in complex with FSTL3
  3hh2		Crystal structure of the myostatin:follistatin 288 complex
  3sek		Crystal Structure of the Myostatin:Follistatin-like 3 Complex

• Links (links to other resources describing this domain)

• INTERPRO	IPR003645

Send comments to Ivica Letunic