GRANGranulin |
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| SMART accession number: | SM00277 |
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| Description: | |
| Interpro abstract (IPR000118): | Metazoan granulins [(PUBMED:1542665)] are a family of cysteine-rich peptides of about 6 Kd which may have multiple biological activity. A precursor protein (known as acrogranin) potentially encodes seven different forms of granulin (grnA to grnG) which are probably released by post-translational proteolytic processing. Granulins are evolutionary related to a PMP-D1, a peptide extracted from the pars intercerebralis of migratory locusts [(PUBMED:1740125)]. A schematic representation of the structure of a granulin is shown below:
In plants a granulin domain is often associated with the C terminus of cysteine proteases belong to the MEROPS peptidase family C1, subfamily C1A (papain). |
| Family alignment: |
There are 635 GRAN domains in 194 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)
to expand nodes. To display all proteins with a GRAN domain in a specific node, click on it.
