GRAN

Granulin
GRAN
SMART accession number:SM00277
Description: -
Interpro abstract (IPR000118):

Metazoan granulins [(PUBMED:1542665)] are a family of cysteine-rich peptides of about 6 Kd which may have multiple biological activity. A precursor protein (known as acrogranin) potentially encodes seven different forms of granulin (grnA to grnG) which are probably released by post-translational proteolytic processing. Granulins are evolutionary related to a PMP-D1, a peptide extracted from the pars intercerebralis of migratory locusts [(PUBMED:1740125)]. A schematic representation of the structure of a granulin is shown below:


xxxCxxxxxCxxxxxCCxxxxxxxxCCxxxxxxCCxxxxxCCxxxxxCxxxxxxCx
'C': conserved cysteine probably involved in a disulphide bond.

In plants a granulin domain is often associated with the C terminus of cysteine proteases belong to the MEROPS peptidase family C1, subfamily C1A (papain).

Family alignment:
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There are 1784 GRAN domains in 488 proteins in SMART's nrdb database.

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