Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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LamB Laminin B domain

SMART accession number:	SM00281
Description:	-
Interpro abstract (IPR000034):	Laminin is a large molecular weight glycoprotein present only in basement membranes in almost every animal tissue. Each laminin is a heterotrimer assembled from alpha, beta and gamma chain subunits, secreted and incorporated into cell-associated extracellular matrices. The laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and other receptors. Through these interactions, laminins critically contribute to cell differentiation, shape and movement, maintenance of tissue phenotypes, and promotion of tissue survival [ (PUBMED:10842354) (PUBMED:15363809) ]. The different laminin chains share a 600-residue domain I/II which oligomerises into a rod-like coiled-coil structure forming the long arm of laminins. The N-terminal short arms consist of rod-like elements (domain III and V) formed by tandem arrays of laminin-type EGF modules and several globular domains: domains IV and domain VI (laminin N-terminal). All alpha chains share a unique C-terminal G domain which consists of five laminin G modules [ (PUBMED:3182802) ]. Laminin IV domain is also found in the perlecan protein, an integral component of basement membranes, which serves also as an attachment substrate for cells, but it is not found in short laminin chains (alpha4 or beta3). The function of this domain is not yet known.
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 7645 LamB domains in 4077 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing LamB domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with LamB domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing LamB domain in the selected taxonomic class.

• Disease (disease genes where sequence variants are found in this domain)

• SwissProt sequences and OMIM curated human diseases associated with missense mutations within the LamB domain.

  Protein	Disease
  Laminin subunit alpha-2 (P24043) (SMART)	OMIM:156225: Muscular dystrophy, congenital merosin-deficient

• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 32.41 map04512 ECM-receptor interaction 28.70 map05222 Small cell lung cancer 28.70 map04510 Focal adhesion 10.19 map05060 Prion disease This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with LamB domain which could be assigned to a KEGG orthologous group, and not all proteins containing LamB domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of LamB domains in PDB

  PDB code	Main view	Title
  4yep		4YEP
  4yeq		4YEQ

• Links (links to other resources describing this domain)

• PFAM	laminin_B
  INTERPRO	IPR000034

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