LamGLaminin G domain
|SMART accession number:||SM00282|
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- Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with LamG domain is also avaliable.
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Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes
- Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Beckmann G, Hanke J, Bork P, Reich JG
- Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins.
- J Mol Biol. 1998; 275: 725-30
- Display abstract
Using a new method for construction and database searches of sequence consensus strings, we have identified a new superfamily of protein modules comprising laminin G, thrombospondin N and the pentraxin families. The conserved patterns correspond mainly to hydrophobic core residues located in central beta strands of the known three-dimensional structures of two pentraxins, the human C-reactive protein and the serum amyloid P-component. Thus, we predict a similar jellyroll fold for all members of this superfamily. In addition, the conservation of two exposed aspartate residues in the majority of superfamily members suggests hitherto unrecognised functional sites.
- Disease (disease genes where sequence variants are found in this domain)
SwissProt sequences and OMIM curated human diseases associated with missense mutations within the LamG domain.
Protein Disease Laminin subunit alpha-2 (P24043) (SMART) OMIM:156225: Muscular dystrophy, congenital merosin-deficient
- Metabolism (metabolic pathways involving proteins which contain this domain)
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% proteins involved KEGG pathway ID Description 27.86 map04512 ECM-receptor interaction 22.39 map04510 Focal adhesion 14.43 map05222 Small cell lung cancer 12.44 map04514 Cell adhesion molecules (CAMs) 8.46 map04360 Axon guidance 3.98 map05060 Prion disease 2.99 map04610 Complement and coagulation cascades 1.99 map00511 N-Glycan degradation 1.99 map00600 Sphingolipid metabolism 1.99 map01032 Glycan structures - degradation 0.50 map00562 Inositol phosphate metabolism 0.50 map04140 Regulation of autophagy 0.50 map04070 Phosphatidylinositol signaling system
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with LamG domain which could be assigned to a KEGG orthologous group, and not all proteins containing LamG domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of LamG domains in PDB
PDB code Main view Title 1c4r The structure of the ligand-binding domain of neurexin 1beta: regulation of lns domain function by alternative splicing 1d2s Crystal structure of the n-terminal laminin g-like domain of shbg in complex with dihydrotestosterone 1dyk Laminin alpha 2 chain lg4-5 domain pair 1f5f Crystal structure of the n-terminal g-domain of shbg in complex with zinc 1h30 C-terminal lg domain pair of human gas6 1kdk The structure of the n-terminal lg domain of shbg in crystals soaked with edta 1kdm The crystal structure of the human sex hormone-binding globulin (tetragonal crystal form) 1lhn Crystal structure of the n-terminal lg-domain of shbg in complex with 5alpha-androstane-3beta,17alpha-diol 1lho Crystal structure of the n-terminal lg-domain of shbg in complex with 5alpha-androstane-3beta,17beta-diol 1lhu Crystal structure of the n-terminal lg-domain of shbg in complex with estradiol 1lhv Crystal structure of the n-terminal lg-domain of shbg in complex with norgestrel 1lhw Crystal structure of the n-terminal lg-domain of shbg in complex with 2-methoxyestradiol 1okq Laminin alpha 2 chain lg4-5 domain pair, ca1 site mutant 1pz7 Modulation of agrin function by alternative splicing and ca2+ binding 1pz8 Modulation of agrin function by alternative splicing and ca2+ binding 1pz9 Modulation of agrin function by alternative splicing and ca2+ binding 1q56 Nmr structure of the b0 isoform of the agrin g3 domain in its ca2+ bound state 1qu0 Crystal structure of the fifth laminin g-like module of the mouse laminin alpha2 chain 1sli Leech intramolecular trans-sialidase complexed with dana 1sll Sialidase l from leech macrobdella decora 2c5d Structure of a minimal gas6-axl complex 2h0b Crystal structure of the second lns/lg domain from neurexin alpha 2jd4 Mouse laminin alpha1 chain, domains lg4-5 2r16 Crystal structure of bovine neurexin 1 alpha lns/lg domain (with no splice insert) 2r1b Crystal structure of rat neurexin 1beta with a splice insert at ss#4 2r1d Crystal structure of rat neurexin 1beta in the ca2+ containing form 2sli Leech intramolecular trans-sialidase complexed with 2,7- anhydro-neu5ac, the reaction product 2wjs Crystal structure of the lg1-3 region of the laminin alpha2 chain 2wqz Crystal structure of synaptic protein neuroligin-4 in complex with neurexin-beta 1: alternative refinement 3b3q Crystal structure of a synaptic adhesion complex 3biw Crystal structure of the neuroligin-1/neurexin-1beta synaptic adhesion complex 3bod Structure of mouse beta-neurexin 1 3bop Structure of mouse beta-neurexin 2d4 3sli Leech intramolecular trans-sialidase complexed with 2,7- anhydro-neu5ac prepared by soaking with 3'-sialyllactose 4sli Leech intramolecular trans-sialidase complexed with 2- propenyl-neu5ac, an inactive substrate analogue
- Links (links to other resources describing this domain)