Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2008) Nucleic Acids Res , doi:10.1093/nar/gkn808

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SH3b Bacterial SH3 domain homologues

There are 1451 SH3b domains in 885 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a SH3b domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with SH3b domain is also avaliable.

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• Cellular role (predicted cellular role)

• Cellular role: signalling
  

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Ponting CP, Aravind L, Schultz J, Bork P, Koonin EV
  • Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer.
  • J Mol Biol. 1999; 289: 729-45
  • Display abstract

  • Phyletic distributions of eukaryotic signalling domains were studied using recently developed sensitive methods for protein sequence analysis, with an emphasis on the detection and accurate enumeration of homologues in bacteria and archaea. A major difference was found between the distributions of enzyme families that are typically found in all three divisions of cellular life and non-enzymatic domain families that are usually eukaryote-specific. Previously undetected bacterial homologues were identified for# plant pathogenesis-related proteins, Pad1, von Willebrand factor type A, src homology 3 and YWTD repeat-containing domains. Comparisons of the domain distributions in eukaryotes and prokaryotes enabled distinctions to be made between the domains originating prior to the last common ancestor of all known life forms and those apparently originating as consequences of horizontal gene transfer events. A number of transfers of signalling domains from eukaryotes to bacteria were confidently identified, in contrast to only a single case of apparent transfer from eukaryotes to archaea.

  • Whisstock JC, Lesk AM
  • SH3 domains in prokaryotes.
  • Trends Biochem Sci. 1999; 24: 132-3
• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 67.50 map00550 Peptidoglycan biosynthesis 5.00 map00511 N-Glycan degradation 5.00 map01032 Glycan structures - degradation 3.75 map00604 Glycosphingolipid biosynthesis - ganglioseries 3.75 map00531 Glycosaminoglycan degradation 3.75 map00530 Aminosugars metabolism 3.75 map00603 Glycosphingolipid biosynthesis - globoseries 2.50 map00240 Pyrimidine metabolism 2.50 map00230 Purine metabolism 2.50 map02010 ABC transporters - General This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with SH3b domain which could be assigned to a KEGG orthologous group, and not all proteins containing SH3b domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of SH3b domains in PDB

  PDB code	Main view	Title
  1r77		Crystal structure of the cell wall targeting domain of peptidylglycan hydrolase ale-1

• Links (links to other resources describing this domain)

• INTERPRO	IPR003646