DM

Doublesex DNA-binding motif
DM
SMART accession number:SM00301
Description:
Interpro abstract (IPR001275): This domain was first discovered in the doublesex proteins of Drosophila melanogaster and is also seen in proteins from Caenorhabditis elegans [(PUBMED:9490411)]. In D. melanogaster the doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides [(PUBMED:8978051)]. These proteins are believed to function as transcription factors on downstream sex-determination genes, especially on neuroblast differentiation and yolk protein genes transcription [(PUBMED:1907913), (PUBMED:3046751)]. The DM domain binds DNA as a dimer, allowing the recognition of pseudopalindromic sequences [(PUBMED:8978051), (PUBMED:9927589), (PUBMED:10898790)]. The NMR analysis of the DSX DM domain [(PUBMED:10898790)] revealed a novel zinc module containing 'intertwined' CCHC and HCCC zinc-binding sites. The recognition of the DNA requires the carboxy-terminal basic tail which contacts the minor groove of the target sequence.
GO process:regulation of transcription, DNA-dependent (GO:0006355), sex differentiation (GO:0007548)
GO component:nucleus (GO:0005634)
GO function:sequence-specific DNA binding (GO:0043565)
Family alignment:
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There are 448 DM domains in 438 proteins in SMART's nrdb database.

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