SNc

Staphylococcal nuclease homologues
SNc
SMART accession number:SM00318
Description: -
Interpro abstract (IPR016071):

Staphylococcus aureus nuclease (SNase) homologues, previously thought to be restricted to bacteria and archaea, are also in eukaryotes. Staphylococcal nuclease has a multi-domain organisation [(PUBMED:9003410)]. The human cellular coactivator p100 contains four repeats, each of which is a SNase homologue. These repeats are unlikely to possess SNase-like activities as each lacks equivalent SNase catalytic residues, yet they may mediate p100's single-stranded DNA-binding function [(PUBMED:9041650)]. A variety of proteins including many that are still uncharacterised belong to this group.

SNase domains have an OB-fold consisting of a closed or partly open beta-barrel with Greek key topology [(PUBMED:8475069)].

Family alignment:
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There are 4706 SNc domains in 3344 proteins in SMART's nrdb database.

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