TarH

Homologues of the ligand binding domain of Tar
TarH
SMART accession number:SM00319
Description: Homologues of the ligand binding domain of the wild-type bacterial aspartate receptor, Tar.
Interpro abstract (IPR003122):

Methyl-accepting chemotaxis proteins (MCPs) are a family of bacterial receptors that mediate chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behaviour [(PUBMED:16359703)]. Environmental diversity gives rise to diversity in bacterial signalling receptors, and consequently there are many genes encoding MCPs [(PUBMED:17299051)]. For example, there are four well-characterised MCPs found in Escherichia coli: Tar (taxis towards aspartate and maltose, away from nickel and cobalt), Tsr (taxis towards serine, away from leucine, indole and weak acids), Trg (taxis towards galactose and ribose) and Tap (taxis towards dipeptides).

MCPs share similar topology and signalling mechanisms. MCPs either bind ligands directly or interact with ligand-binding proteins, transducing the signal to downstream signalling proteins in the cytoplasm. MCPs undergo two covalent modifications: deamidation and reversible methylation at a number of glutamate residues. Attractants increase the level of methylation, while repellents decrease it. The methyl groups are added by the methyl-transferase cheR and are removed by the methylesterase cheB. Most MCPs are homodimers that contain the following organisation: an N-terminal signal sequence that acts as a transmembrane domain in the mature protein; a poorly-conserved periplasmic receptor (ligand-binding) domain; a second transmembrane domain; and a highly-conserved C-terminal cytoplasmic domain that interacts with downstream signalling components. The C-terminal domain contains the glycosylated glutamate residues.

This entry represents the ligand-binding domain found in a number of methyl-accepting chemotaxis receptors.

GO process:chemotaxis (GO:0006935), signal transduction (GO:0007165)
GO component:membrane (GO:0016020)
GO function:transmembrane signaling receptor activity (GO:0004888)
Family alignment:
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There are 1360 TarH domains in 1360 proteins in SMART's nrdb database.

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