Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2008) Nucleic Acids Res , doi:10.1093/nar/gkn808

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KH K homology RNA-binding domain

There are 8776 KH domains in 5116 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a KH domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with KH domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Binding / catalysis: RNA-binding

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Lewis HA et al.
  • Sequence-specific RNA binding by a Nova KH domain: implications for paraneoplastic disease and the fragile X syndrome.
  • Cell. 2000; 100: 323-32
  • Display abstract

  • The structure of a Nova protein K homology (KH) domain recognizing single-stranded RNA has been determined at 2.4 A resolution. Mammalian Nova antigens (1 and 2) constitute an important family of regulators of RNA metabolism in neurons, first identified using sera from cancer patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA). The structure of the third KH domain (KH3) of Nova-2 bound to a stem loop RNA resembles a molecular vise, with 5'-Ura-Cyt-Ade-Cyt-3' pinioned between an invariant Gly-X-X-Gly motif and the variable loop. Tetranucleotide recognition is supported by an aliphatic alpha helix/beta sheet RNA-binding platform, which mimics 5'-Ura-Gua-3' by making Watson-Crick-like hydrogen bonds with 5'-Cyt-Ade-3'. Sequence conservation suggests that fragile X mental retardation results from perturbation of RNA binding by the FMR1 protein.

  • Adinolfi S, Bagni C, Musco G, Gibson T, Mazzarella L, Pastore A
  • Dissecting FMR1, the protein responsible for fragile X syndrome, in its structural and functional domains.
  • RNA. 1999; 5: 1248-58
  • Display abstract

  • FMR1 is an RNA-binding protein that is either absent or mutated in patients affected by the fragile X syndrome, the most common inherited cause of mental retardation in humans. Sequence analysis of the FMR1 protein has suggested that RNA binding is related to the presence of two K-homologous (KH) modules and an RGG box. However, no attempt has been so far made to map the RNA-binding sites along the protein sequence and to identify possible differential RNA-sequence specificity. In the present article, we describe work done to dissect FMR1 into regions with structurally and functionally distinct properties. A semirational approach was followed to identify four regions: an N-terminal stretch of 200 amino acids, the two KH regions, and a C-terminal stretch. Each region was produced as a recombinant protein, purified, and probed for its state of folding by spectroscopical techniques. Circular dichroism and NMR spectra of the N-terminus show formation of secondary structure with a strong tendency to aggregate. Of the two homologous KH motifs, only the first one is folded whereas the second remains unfolded even when it is extended both N- and C-terminally. The C-terminus is, as expected from its amino acid composition, nonglobular. Binding assays were then performed using the 4-nt homopolymers. Our results show that only the first KH domain but not the second binds to RNA, and provide the first direct evidence for RNA binding of both the N-terminal and the C-terminal regions. RNA binding for the N-terminus could not be predicted from sequence analysis because no known RNA-binding motif is identifiable in this region. Different sequence specificity was observed for the fragments: both the N-terminus of the protein and KH1 bind preferentially to poly-(rG). The C-terminal region, which contains the RGG box, is nonspecific, as it recognizes the bases with comparable affinity. We therefore conclude that FMR1 is a protein with multiple sites of interaction with RNA: sequence specificity is most likely achieved by the whole block that comprises the first approximately 400 residues, whereas the C-terminus provides a nonspecific binding surface.

  • Ostareck-Lederer A, Ostareck DH, Hentze MW
  • Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2.
  • Trends Biochem Sci. 1998; 23: 409-11

  • Musco G et al.
  • The solution structure of the first KH domain of FMR1, the protein responsible for the fragile X syndrome.
  • Nat Struct Biol. 1997; 4: 712-6

  • Musco G et al.
  • Three-dimensional structure and stability of the KH domain: molecular insights into the fragile X syndrome.
  • Cell. 1996; 85: 237-45
  • Display abstract

  • The KH module is a sequence motif found in a number of proteins that are known to be in close association with RNA. Experimental evidence suggests a direct involvement of KH in RNA binding. The human FMR1 protein, which has two KH domains, is associated with fragile X syndrome, the most common inherited cause of mental retardation. Here we present the three-dimensional solution structure of the KH module. The domain consists of a stable beta alpha alpha beta beta alpha fold. On the basis of our results, we suggest a potential surface for RNA binding centered on the loop between the first two helices. Substitution of a well-conserved hydrophobic residue located on the second helix destroys the KH fold; a mutation of this position in FMR1 leads to an aggravated fragile X phenotype.

  • Siomi H, Choi M, Siomi MC, Nussbaum RL, Dreyfuss G
  • Essential role for KH domains in RNA binding: impaired RNA binding by a mutation in the KH domain of FMR1 that causes fragile X syndrome.
  • Cell. 1994; 77: 33-9
  • Display abstract

  • The KH domain is an evolutionarily conserved sequence motif present in many RNA-binding proteins, including the pre-mRNA-binding (hnRNP) K protein and the fragile X mental retardation gene product (FMR1). We assessed the role of KH domains in RNA binding by mutagenesis of KH domains in hnRNP K and FMR1. Conserved residues of all three hnRNP K KH domains are required for its wild-type RNA binding. Interestingly, while fragile X syndrome is usually caused by lack of FMR1 expression, a previously reported mutation in a highly conserved residue of one of its two KH domains (Ile-304-->Asn) also results in mental retardation. We found that the binding of this mutant protein to RNA is severely impaired. These results demonstrate an essential role for KH domains in RNA binding. Furthermore, they strengthen the connection between fragile X syndrome and loss of the RNA binding activity of FMR1.

• Disease (disease genes where sequence variants are found in this domain)

• SwissProt sequences and OMIM curated human diseases associated with missense mutations within the KH domain.

  Protein	Disease
  Fragile X mental retardation 1 protein (SRS)(SMART)	OMIM:309550: Fragile X syndrome

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 34.62 map00240 Pyrimidine metabolism 34.62 map00230 Purine metabolism 29.68 map03010 Ribosome 1.00 map02010 ABC transporters - General 0.08 map00190 Oxidative phosphorylation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with KH domain which could be assigned to a KEGG orthologous group, and not all proteins containing KH domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of KH domains in PDB

  PDB code	Main view	Title
  1dt4		Crystal structure of nova-1 kh3 k-homology rna-binding domain
  1dtj		Crystal structure of nova-2 kh3 k-homology rna-binding domain
  1e3h		Semet derivative of streptomyces antibioticus pnpase/gpsi enzyme
  1e3p		Tungstate derivative of streptomyces antibioticus pnpase/ gpsi enzyme
  1ec6		Crystal structure of nova-2 kh3 k-homology rna-binding domain bound to 20-mer rna hairpin
  1fjg		Structure of the thermus thermophilus 30s ribosomal subunit in complex with the antibiotics streptomycin, spectinomycin, and paromomycin
  1gix		Crystal structure of the ribosome at 5.5 a resolution. this file, 1gix, contains the 30s ribosome subunit, three trna, and mrna molecules. 50s ribosome subunit is in the file 1giy
  1hh2		Crystal structure of nusa from thermotoga maritima
  1hnw		Structure of the thermus thermophilus 30s ribosomal subunit in complex with tetracycline
  1hnx		Structure of the thermus thermophilus 30s ribosomal subunit in complex with pactamycin
  1hnz		Structure of the thermus thermophilus 30s ribosomal subunit in complex with hygromycin b
  1hr0		Crystal structure of initiation factor if1 bound to the 30s ribosomal subunit
  1i94		Crystal structures of the small ribosomal subunit with tetracycline, edeine and if3
  1i95		Crystal structure of the 30s ribosomal subunit from thermus thermophilus in complex with edeine
  1i96		Crystal structure of the 30s ribosomal subunit from thermus thermophilus in complex with the translation initiation factor if3 (c-terminal domain)
  1i97		Crystal structure of the 30s ribosomal subunit from thermus thermophilus in complex with tetracycline
  1ibk		Structure of the thermus thermophilus 30s ribosomal subunit in complex with the antibiotic paromomycin
  1ibl		Structure of the thermus thermophilus 30s ribosomal subunit in complex with a messenger rna fragment and cognate transfer rna anticodon stem-loop bound at the a site and with the antibiotic paromomycin
  1ibm		Structure of the thermus thermophilus 30s ribosomal subunit in complex with a messenger rna fragment and cognate transfer rna anticodon stem-loop bound at the a site
  1j4w		Complex of the kh3 and kh4 domains of fbp with a single_stranded 29mer dna oligonucleotide from the fuse element of the c-myc oncogene
  1j5e		Structure of the thermus thermophilus 30s ribosomal subunit
  1j5k		Complex of the kh3 domain of hnrnp k with a single_stranded 10mer dna oligonucleotide
  1jgo		The path of messenger rna through the ribosome. this file, 1jgo, contains the 30s ribosome subunit, three trna, and mrna molecules. 50s ribosome subunit is in the file 1giy
  1jgp		The path of messenger rna through the ribosome. this file, 1jgp, contains the 30s ribosome subunit, three trna, and mrna molecules. 50s ribosome subunit is in the file 1giy
  1jgq		The path of messenger rna through the ribosome. this file, 1jgq, contains the 30s ribosome subunit, three trna, and mrna molecules. 50s ribosome subunit is in the file 1giy
  1k0r		Crystal structure of mycobacterium tuberculosis nusa
  1k1g		Structural basis for recognition of the intron branch site rna by splicing factor 1
  1khm		C-terminal kh domain of hnrnp k (kh3)
  1l2f		Crystal structure of nusa from thermotoga maritima: a structure-based role of the n-terminal domain
  1ml5		Structure of the e. coli ribosomal termination complex with release factor 2
  1n32		Structure of the thermus thermophilus 30s ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the first codon position at the a site with paromomycin
  1n33		Structure of the thermus thermophilus 30s ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position at the a site with paromomycin
  1n34		Structure of the thermus thermophilus 30s ribosomal subunit in the presence of codon and crystallographically disordered near-cognate transfer rna anticodon stem-loop mismatched at the first codon position
  1n36		Structure of the thermus thermophilus 30s ribosomal subunit in the presence of crystallographically disordered codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position
  1p6g		Real space refined coordinates of the 30s subunit fitted into the low resolution cryo-em map of the ef-g.gtp state of e. coli 70s ribosome
  1p87		Real space refined coordinates of the 30s subunit fitted into the low resolution cryo-em map of the initiation-like state of e. coli 70s ribosome
  1pns		Crystal structure of a streptomycin dependent ribosome from e. coli, 30s subunit of 70s ribosome. this file, 1pns, contains the 30s subunit, two trnas, and one mrna molecule. the 50s ribosomal subunit is in file 1pnu.
  1pnx		Crystal structure of the wild type ribosome from e. coli, 30s subunit of 70s ribosome. this file, 1pnx, contains only molecules of the 30s ribosomal subunit. the 50s subunit is in the pdb file 1pny.
  1s1h		Structure of the ribosomal 80s-eef2-sordarin complex from yeast obtained by docking atomic models for rna and protein components into a 11.7 a cryo-em map. this file, 1s1h, contains 40s subunit. the 60s ribosomal subunit is in file 1s1i.
  1tua		1.5 a crystal structure of a protein of unknown function ape0754 from aeropyrum pernix
  1vig		Nmr study of vigilin, repeat 6, 40 structures
  1vih		Nmr study of vigilin, repeat 6, minimized average structure
  1voq		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
  1vos		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
  1vov		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
  1vox		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
  1voz		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
  1vs5		Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  1vs7		Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  1we8		Solution structure of kh domain in protein bab28342
  1wvn		Crsytal structure of domain 3 of human alpha polyc binding protein
  1x4m		Solution structure of kh domain in far upstream element binding protein 1
  1x4n		Solution structure of kh domain in fuse binding protein 1
  1xmo		Crystal structure of mnm5u34t6a37-trnalysuuu complexed with aag-mrna in the decoding center
  1xmq		Crystal structure of t6a37-asllysuuu aaa-mrna bound to the decoding center
  1xnq		Structure of an inosine-adenine wobble base pair complex in the context of the decoding center
  1xnr		Crystal structure of an inosine-cytosine wobble base pair in the context of the decoding center
  1yl4		Crystal structure of 70s ribosome with thrs operator and trnas. 30s subunit. the coordinates for the 50s subunit are in the pdb entry 1yl3
  1ztg		Human alpha polyc binding protein kh1
  1zzi		Crystal structure analysis of the third kh domain of hnrnp k in complex with ssdna
  1zzj		Structure of the third kh domain of hnrnp k in complex with 15-mer ssdna
  1zzk		Crystal structure of the third kh domain of hnrnp k at 0.95a resolution
  2ann		Crystal structure (i) of nova-1 kh1/kh2 domain tandem with nt rna hairpin
  2anr		Crystal structure (ii) of nova-1 kh1/kh2 domain tandem with 25nt rna hairpin
  2asb		Structure of a mycobacterium tuberculosis nusa-rna complex
  2atw		Structure of a mycobacterium tuberculosis nusa-rna complex
  2avy		Crystal structure of the bacterial ribosome from escherichia coli at 3.5 a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2aw7		Crystal structure of the bacterial ribosome from escherichia coli at 3.5 a resolution. this file contains the 30s subunit of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2axy		Crystal structure of kh1 domain of human poly(c)-binding protein-2 with c-rich strand of human telomeric dna
  2b64		30s ribosomal subunit, trnas, mrna and release factor rf1 from a crystal structure of the whole ribosomal complex. this file contains the 30s subunit, trnas, mrna and release factor rf1 from a crystal structure of the whole ribosomal complex". the entire crystal structure contains one 70s ribosome, trnas, mrna and release factor rf1 and is described in remark 400.
  2b9m		30s ribosomal subunit, trnas, mrna and release factor rf2 from a crystal structure of the whole ribosomal complex. this file contains the 30s ribosomal subunit, trnas, mrna and release factor rf2 from a crystal structure of the whole ribosomal complex". the entire crystal structure contains one 70s ribosome, trnas, mrna and release factor rf2 and is described in remark 400.
  2b9o		30s ribosomal subunit, trnas and mrna from a crystal structure of the whole ribosomal complex with a stop codon in the a-site. this file contains the 30s subunit, trnas and mrna from a crystal structure of the whole ribosomal complex with a stop codon in the a-site and is described in remark 400.
  2ba0		Archaeal exosome core
  2bl5		Solution structure of the kh-qua2 region of the xenopus star-gsg quaking protein.
  2cpq		Solution structure of the n-terminal kh domain of human fxr1
  2cte		Solution structure of the 1st kh type i domain from human vigilin
  2ctf		Solution structure of the 4th kh type i domain from human vigilin
  2ctj		Solution structure of the 8th kh type i domain from human vigilin
  2ctk		Solution structure of the 12th kh type i domain from human vigilin
  2ctl		Solution structure of the 13th kh type i domain from human vigilin
  2ctm		Solution structure of the 14th kh type i domain from human vigilin
  2cxc		Crystal structure of archaeal transcription termination factor nusa
  2cy1		Crystal structure of ape1850
  2dgr		Solution structure of the second kh domain in ring finger and kh domain containing protein 1
  2e3u		Crystal structure analysis of dim2p from pyrococcus horikoshii ot3
  2e5l		A snapshot of the 30s ribosomal subunit capturing mrna via the shine- dalgarno interaction
  2f4v		30s ribosome + designer antibiotic
  2fmr		Kh1 from the fragile x protein fmr1, nmr, 18 structures
  2gy9		Structure of the 30s subunit of a pre-translocational e. coli ribosome obtained by fitting atomic models for rna and protein components into cryo-em map emd-1056
  2gyb		Structure of the 30s subunit of a secm-stalled e. coli ribosome complex obtained by fitting atomic models for rna and protein components into cryo-em map emd-1143
  2hgi		Crystal structure of the 70s thermus thermophilus ribosome showing how the 16s 3'-end mimicks mrna e and p codons. this entry 2hgi contains 30s ribosomal subunit. the 50s ribosomal subunit can be found in pdb entry 2hgj.
  2hgp		Crystal structure of the 70s thermus thermophilus ribosome with translocated and rotated shine-dalgarno duplex. this entry 2hgp contains 30s ribosomal subunit. the 50s ribosomal subunit can be found in pdb entry 2hgq.
  2hgr		70s t.th. ribosome functional complex with mrna and e- and p-site trnas at 4.5a. this entry 2hgr contains 30s ribosomal subunit. the 50s ribosomal subunit can be found in pdb entry 2hgu.
  2hh2		Solution structure of the fourth kh domain of ksrp
  2hh3		Solution structure of the third kh domain of ksrp
  2hhh		Crystal structure of kasugamycin bound to the 30s ribosomal subunit
  2i2p		Crystal structure of ribosome with messenger rna and the anticodon stem-loop of p-site trna. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2i2u		Crystal structure of ribosome with messenger rna and the anticodon stem-loop of p-site trna. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2j00		Structure of the thermus thermophilus 70s ribosome complexed with mrna, trna and paromomycin (part 1 of 4). this file contains the 30s subunit, mrna, a-, p- and e- site trnas and paromomycin for molecule i.
  2j02		Structure of the thermus thermophilus 70s ribosome complexed with mrna, trna and paromomycin (part 3 of 4) this file contains the 30s subunit, mrna, a-, p- and e- site trnas and paromomycin for molecule ii.
  2je6		Structure of a 9-subunit archaeal exosome
  2jea		Structure of a 9-subunit archaeal exosome bound to rna
  2jeb		Structure of a 9-subunit archaeal exosome bound to mn ions
  2jvz
  2jzx		Pcbp2 kh1-kh2 domains
  2opu		Solution nmr structure of the first domain of ksrp
  2opv		Solution nmr structure of the second domain of ksrp
  2ow8		Crystal structure of a 70s ribosome-trna complex reveals functional interactions and rearrangements. this file, 2ow8, contains the 30s ribosome subunit, two trna, and mrna molecules. 50s ribosome subunit is in the file 1vsa.
  2p2r		Crystal structure of the third kh domain of human poly(c)- binding protein-2 in complex with c-rich strand of human telomeric dna
  2pqu		Crystal structure of kh1 domain of human pcbp2 complexed to single-stranded 12-mer telomeric dna
  2py9		Protein-rna interaction involving kh1 domain from human poly(c)-binding protein-2
  2qal		Crystal structure of the bacterial ribosome from escherichia coli in complex with neomycin. this file contains the 30s subunit of the first 70s ribosome, with neomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2qan		Crystal structure of the bacterial ribosome from escherichia coli in complex with neomycin. this file contains the 30s subunit of the second 70s ribosome, with neomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2qb9		Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin. this file contains the 30s subunit of the first 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2qbb		Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin. this file contains the 30s subunit of the second 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2qbd		Crystal structure of the bacterial ribosome from escherichia coli in complex with ribosome recycling factor (rrf). this file contains the 30s subunit of the first 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2qbf		Crystal structure of the bacterial ribosome from escherichia coli in complex with ribosome recycling factor (rrf). this file contains the 30s subunit of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2qbh		Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin and ribosome recycling factor (rrf). this file contains the 30s subunit of the first 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2qbj		Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin and ribosome recycling factor (rrf). this file contains the 30s subunit of the second 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2qnd		Crystal structure of the kh1-kh2 domains from human fragile x mental retardation protein
  2qnh		Interactions and dynamics of the shine-dalgarno helix in the 70s ribosome. this file, 2qnh, contains the 30s ribosome subunit, two trna, and mrna molecules. 50s ribosome subunit is in the file 1vsp.
  2qou		Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin. this file contains the 30s subunit of the first 70s ribosome, with spectinomycin bound. the entire crystal structure contains two 70s ribosomes.
  2qow		Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin. this file contains the 30s subunit of the second 70s ribosome, with spectinomycin bound. the entire crystal structure contains two 70s ribosomes.
  2qoy		Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin and neomycin. this file contains the 30s subunit of the first 70s ribosome, with spectinomycin and neomycin bound. the entire crystal structure contains two 70s ribosomes.
  2qp0		Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin and neomycin. this file contains the 30s subunit of the second 70s ribosome, with spectinomycin and neomycin bound. the entire crystal structure contains two 70s ribosomes.
  2uu9		Structure of the thermus thermophilus 30s ribosomal subunit complexed with a valine-asl with cmo5u in position 34 bound to an mrna with a gug-codon in the a-site and paromomycin.
  2uua		Structure of the thermus thermophilus 30s ribosomal subunit complexed with a valine-asl with cmo5u in position 34 bound to an mrna with a guc-codon in the a-site and paromomycin.
  2uub		Structure of the thermus thermophilus 30s ribosomal subunit complexed with a valine-asl with cmo5u in position 34 bound to an mrna with a guu-codon in the a-site and paromomycin.
  2uuc		Structure of the thermus thermophilus 30s ribosomal subunit complexed with a valine-asl with cmo5u in position 34 bound to an mrna with a gua-codon in the a-site and paromomycin.
  2uxb		Crystal structure of an extended trna anticodon stem loop in complex with its cognate mrna gggu in the context of the thermus thermophilus 30s subunit.
  2uxc		Crystal structure of an extended trna anticodon stem loop in complex with its cognate mrna ucgu in the context of the thermus thermophilus 30s subunit.
  2uxd		Crystal structure of an extended trna anticodon stem loop in complex with its cognate mrna cggg in the context of the thermus thermophilus 30s subunit.
  2v46		Structure of the ribosome recycling factor bound to the thermus thermophilus 70s ribosome with mrna, asl-phe and trna-fmet (part 1 of 4). this file contains the 30s subunit, mrna, p-site asl, e-site trna and rrf for molecule 1.
  2v48		Structure of the ribosome recycling factor bound to the thermus thermophilus 70s ribosome with mrna, asl-phe and trna-fmet (part 3 of 4). this file contains the 30s subunit, mrna, p-site asl, e-site trna and rrf for molecule 2.
  2vho		Structure of pdf binding helix in complex with the ribosome (part 3 of 4)
  2vhp		Structure of pdf binding helix in complex with the ribosome (part 4 of 4)
  2vqe		Modified uridines with c5-methylene substituents at the first position of the trna anticodon stabilize u-g wobble pairing during decoding
  2vqf		Modified uridines with c5-methylene substituents at the first position of the trna anticodon stabilize u-g wobble pairing during decoding
  2wdg
  2wdh
  2wdk
  2wdm
  2wh1
  2wh3
  2wri
  2wrk
  2wrn
  2wrq
  2z0s		Crystal structure of putative exosome complex rna-binding protein
  2z4k		Crystal structure of the bacterial ribosome from escherichia coli in complex with paromomycin and ribosome recycling factor (rrf). this file contains the 30s subunit of the first 70s ribosome, with paromomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2z4m		Crystal structure of the bacterial ribosome from escherichia coli in complex with paromomycin and ribosome recycling factor (rrf). this file contains the 30s subunit of the second 70s ribosome, with paromomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
  2zkq		Structure of a mammalian ribosomal 40s subunit within an 80s complex obtained by docking homology models of the rna and proteins into an 8.7 a cryo-em map
  2zm6
  3cdi
  3d5a
  3d5c
  3df1		Crystal structure of the bacterial ribosome from escherichia coli in complex with hygromycin b. this file contains the 30s subunit of the first 70s ribosome, with hygromycin b bound. the entire crystal structure contains two 70s ribosomes.
  3df3		Crystal structure of the bacterial ribosome from escherichia coli in complex with hygromycin b. this file contains the 30s subunit of the second 70s ribosome, with hygromycin b bound. the entire crystal structure contains two 70s ribosomes.
  3e1a
  3e1c
  3f1e
  3f1g
  3fic
  3fih
  3gku
  3huw
  3huy
  3i1m
  3i1o
  3i1q
  3i1s
  3i1z
  3i21

• Links (links to other resources describing this domain)

• PFAM	KH-domain
  INTERPRO	IPR004087