SMART: S4 domain annotation

S4 S4 RNA-binding domain

SMART accession number:	SM00363
Description:
Interpro abstract (IPR002942):	The S4 domain is a small domain consisting of 60-65 amino acid residues that was detected in the bacterial ribosomal protein S4, eukaryotic ribosomal S9, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterised, small proteins that may be involved in translation regulation [(PUBMED:10093218)]. The S4 domain probably mediates binding to RNA [(PUBMED:9707415)].
GO function:	RNA binding (GO:0003723)
Family alignment:	View or

There are 15211 S4 domains in 15206 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with S4 domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Cellular role (predicted cellular role)
Binding / catalysis: RNA-binding
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Aravind L, Koonin EV
- Novel predicted RNA-binding domains associated with the translation machinery.
- J Mol Evol. 1999; 48: 291-302
- Display abstract
- Two previously undetected domains were identified in a variety of RNA-binding proteins, particularly RNA-modifying enzymes, using methods for sequence profile analysis. A small domain consisting of 60-65 amino acid residues was detected in the ribosomal protein S4, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation. Another novel domain, designated PUA domain, after PseudoUridine synthase and Archaeosine transglycosylase, was detected in archaeal and eukaryotic pseudouridine synthases, archaeal archaeosine synthases, a family of predicted ATPases that may be involved in RNA modification, a family of predicted archaeal and bacterial rRNA methylases. Additionally, the PUA domain was detected in a family of eukaryotic proteins that also contain a domain homologous to the translation initiation factor eIF1/SUI1; these proteins may comprise a novel type of translation factors. Unexpectedly, the PUA domain was detected also in bacterial and yeast glutamate kinases; this is compatible with the demonstrated role of these enzymes in the regulation of the expression of other genes. We propose that the S4 domain and the PUA domain bind RNA molecules with complex folded structures, adding to the growing collection of nucleic acid-binding domains associated with DNA and RNA modification enzymes. The evolution of the translation machinery components containing the S4, PUA, and SUI1 domains must have included several events of lateral gene transfer and gene loss as well as lineage-specific domain fusions.
- Markus MA, Gerstner RB, Draper DE, Torchia DA
- The solution structure of ribosomal protein S4 delta41 reveals two subdomains and a positively charged surface that may interact with RNA.
- EMBO J. 1998; 17: 4559-71
- Display abstract
- S4 is one of the first proteins to bind to 16S RNA during assembly of the prokaryotic ribosome. Residues 43-200 of S4 from Bacillus stearothermophilus (S4 Delta41) bind specifically to both 16S rRNA and to a pseudoknot within the alpha operon mRNA. As a first step toward understanding how S4 recognizes and organizes RNA, we have solved the structure of S4 Delta41 in solution by multidimensional heteronuclear nuclear magnetic resonance spectroscopy. The fold consists of two globular subdomains, one comprised of four helices and the other comprised of a five-stranded antiparallel beta-sheet and three helices. Although cross-linking studies suggest that residues between helices alpha2 and alpha3 are close to RNA, the concentration of positive charge along the crevice between the two subdomains suggests that this could be an RNA-binding site. In contrast to the L11 RNA-binding domain studied previously, S4 Delta41 shows no fast local motions, suggesting that it has less capacity for refolding to fit RNA. The independently determined crystal structure of S4 Delta41 shows similar features, although there is small rotation of the subdomains compared with the solution structure. The relative orientation of the subdomains in solution will be verified with further study.
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

3D Structures of S4 domains in PDB

PDB code	Main view	Title
1c05		Solution structure of ribosomal protein s4 delta 41, refined with dipolar couplings (minimized average structure)
1c06		Solution structure of ribosomal protein s4 delta 41, refined with dipolar couplings (ensemble of 16 structures)
1dm9		Heat shock protein 15 kd
1eg0		Fitting of components with known structure into an 11.5 a cryo-em map of the e.coli 70s ribosome
1fjg		Structure of the thermus thermophilus 30s ribosomal subunit in complex with the antibiotics streptomycin, spectinomycin, and paromomycin
1fka		Structure of functionally activated small ribosomal subunit at 3.3 a resolution
1gix		Crystal structure of the ribosome at 5.5 a resolution. this file, 1gix, contains the 30s ribosome subunit, three trna, and mrna molecules. 50s ribosome subunit is in the file 1giy
1h3e		Tyrosyl-trna synthetase from thermus thermophilus complexed with wild-type trnatyr(gua) and with atp and tyrosinol
1h3f		Tyrosyl-trna synthetase from thermus thermophilus complexed with tyrosinol
1hnw		Structure of the thermus thermophilus 30s ribosomal subunit in complex with tetracycline
1hnx		Structure of the thermus thermophilus 30s ribosomal subunit in complex with pactamycin
1hnz		Structure of the thermus thermophilus 30s ribosomal subunit in complex with hygromycin b
1hr0		Crystal structure of initiation factor if1 bound to the 30s ribosomal subunit
1i94		Crystal structures of the small ribosomal subunit with tetracycline, edeine and if3
1i95		Crystal structure of the 30s ribosomal subunit from thermus thermophilus in complex with edeine
1i96		Crystal structure of the 30s ribosomal subunit from thermus thermophilus in complex with the translation initiation factor if3 (c-terminal domain)
1i97		Crystal structure of the 30s ribosomal subunit from thermus thermophilus in complex with tetracycline
1ibk		Structure of the thermus thermophilus 30s ribosomal subunit in complex with the antibiotic paromomycin
1ibl		Structure of the thermus thermophilus 30s ribosomal subunit in complex with a messenger rna fragment and cognate transfer rna anticodon stem-loop bound at the a site and with the antibiotic paromomycin
1ibm		Structure of the thermus thermophilus 30s ribosomal subunit in complex with a messenger rna fragment and cognate transfer rna anticodon stem-loop bound at the a site
1j5e		Structure of the thermus thermophilus 30s ribosomal subunit
1jgo		The path of messenger rna through the ribosome. this file, 1jgo, contains the 30s ribosome subunit, three trna, and mrna molecules. 50s ribosome subunit is in the file 1giy
1jgp		The path of messenger rna through the ribosome. this file, 1jgp, contains the 30s ribosome subunit, three trna, and mrna molecules. 50s ribosome subunit is in the file 1giy
1jgq		The path of messenger rna through the ribosome. this file, 1jgq, contains the 30s ribosome subunit, three trna, and mrna molecules. 50s ribosome subunit is in the file 1giy
1jh3		Solution structure of tyrosyl-trna synthetase c-terminal domain.
1jii		Crystal structure of s. aureus tyrrs in complex with sb-
1jij		Crystal structure of s. aureus tyrrs in complex with sb-
1jik		Crystal structure of s. aureus tyrrs in complex with sb-
1jil		Crystal structure of s. aureus tyrrs in complex with sb284485
1ksk		Structure of rsua
1ksl		Structure of rsua
1ksv		Structure of rsua
1ml5		Structure of the e. coli ribosomal termination complex with release factor 2
1n32		Structure of the thermus thermophilus 30s ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the first codon position at the a site with paromomycin
1n33		Structure of the thermus thermophilus 30s ribosomal subunit bound to codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position at the a site with paromomycin
1n34		Structure of the thermus thermophilus 30s ribosomal subunit in the presence of codon and crystallographically disordered near-cognate transfer rna anticodon stem-loop mismatched at the first codon position
1n36		Structure of the thermus thermophilus 30s ribosomal subunit in the presence of crystallographically disordered codon and near-cognate transfer rna anticodon stem-loop mismatched at the second codon position
1p6g		Real space refined coordinates of the 30s subunit fitted into the low resolution cryo-em map of the ef-g.gtp state of e. coli 70s ribosome
1p87		Real space refined coordinates of the 30s subunit fitted into the low resolution cryo-em map of the initiation-like state of e. coli 70s ribosome
1pns		Crystal structure of a streptomycin dependent ribosome from e. coli, 30s subunit of 70s ribosome. this file, 1pns, contains the 30s subunit, two trnas, and one mrna molecule. the 50s ribosomal subunit is in file 1pnu.
1pnx		Crystal structure of the wild type ribosome from e. coli, 30s subunit of 70s ribosome. this file, 1pnx, contains only molecules of the 30s ribosomal subunit. the 50s subunit is in the pdb file 1pny.
1qd7		Partial model for 30s ribosomal subunit
1qyu		Structure of the catalytic domain of 23s rrna pseudouridine synthase rlud
1s1h		Structure of the ribosomal 80s-eef2-sordarin complex from yeast obtained by docking atomic models for rna and protein components into a 11.7 a cryo-em map. this file, 1s1h, contains 40s subunit. the 60s ribosomal subunit is in file 1s1i.
1v9f		Crystal structure of catalytic domain of pseudouridine synthase rlud from escherichia coli
1vio		Crystal structure of pseudouridylate synthase
1voq		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
1vos		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
1vov		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
1vox		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
1voz		Crystal structure of five 70s ribosomes from escherichia coli in complex with protein y. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains five 70s ribosomes and is described in remark 400.
1vs5		Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
1vs7		Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
1xmo		Crystal structure of mnm5u34t6a37-trnalysuuu complexed with aag-mrna in the decoding center
1xmq		Crystal structure of t6a37-asllysuuu aaa-mrna bound to the decoding center
1xnq		Structure of an inosine-adenine wobble base pair complex in the context of the decoding center
1xnr		Crystal structure of an inosine-cytosine wobble base pair in the context of the decoding center
1yl4		Crystal structure of 70s ribosome with thrs operator and trnas. 30s subunit. the coordinates for the 50s subunit are in the pdb entry 1yl3
2avy		Crystal structure of the bacterial ribosome from escherichia coli at 3.5 a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2aw7		Crystal structure of the bacterial ribosome from escherichia coli at 3.5 a resolution. this file contains the 30s subunit of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2b64		30s ribosomal subunit, trnas, mrna and release factor rf1 from a crystal structure of the whole ribosomal complex. this file contains the 30s subunit, trnas, mrna and release factor rf1 from a crystal structure of the whole ribosomal complex". the entire crystal structure contains one 70s ribosome, trnas, mrna and release factor rf1 and is described in remark 400.
2b9m		30s ribosomal subunit, trnas, mrna and release factor rf2 from a crystal structure of the whole ribosomal complex. this file contains the 30s ribosomal subunit, trnas, mrna and release factor rf2 from a crystal structure of the whole ribosomal complex". the entire crystal structure contains one 70s ribosome, trnas, mrna and release factor rf2 and is described in remark 400.
2b9o		30s ribosomal subunit, trnas and mrna from a crystal structure of the whole ribosomal complex with a stop codon in the a-site. this file contains the 30s subunit, trnas and mrna from a crystal structure of the whole ribosomal complex with a stop codon in the a-site and is described in remark 400.
2cqj		Solution structure of the s4 domain of u3 small nucleolar ribonucleoprotein protein imp3 homolog
2e5l		A snapshot of the 30s ribosomal subunit capturing mrna via the shine- dalgarno interaction
2f4v		30s ribosome + designer antibiotic
2gy9		Structure of the 30s subunit of a pre-translocational e. coli ribosome obtained by fitting atomic models for rna and protein components into cryo-em map emd-1056
2gyb		Structure of the 30s subunit of a secm-stalled e. coli ribosome complex obtained by fitting atomic models for rna and protein components into cryo-em map emd-1143
2hgi		Crystal structure of the 70s thermus thermophilus ribosome showing how the 16s 3'-end mimicks mrna e and p codons. this entry 2hgi contains 30s ribosomal subunit. the 50s ribosomal subunit can be found in pdb entry 2hgj.
2hgp		Crystal structure of the 70s thermus thermophilus ribosome with translocated and rotated shine-dalgarno duplex. this entry 2hgp contains 30s ribosomal subunit. the 50s ribosomal subunit can be found in pdb entry 2hgq.
2hgr		70s t.th. ribosome functional complex with mrna and e- and p-site trnas at 4.5a. this entry 2hgr contains 30s ribosomal subunit. the 50s ribosomal subunit can be found in pdb entry 2hgu.
2hhh		Crystal structure of kasugamycin bound to the 30s ribosomal subunit
2i2p		Crystal structure of ribosome with messenger rna and the anticodon stem-loop of p-site trna. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2i2u		Crystal structure of ribosome with messenger rna and the anticodon stem-loop of p-site trna. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2ist		Crystal structure of rlud from e. coli
2j00		Structure of the thermus thermophilus 70s ribosome complexed with mrna, trna and paromomycin (part 1 of 4). this file contains the 30s subunit, mrna, a-, p- and e-site trnas and paromomycin for molecule i.
2j02		Structure of the thermus thermophilus 70s ribosome complexed with mrna, trna and paromomycin (part 3 of 4) this file contains the 30s subunit, mrna, a-, p- and e-site trnas and paromomycin for molecule ii.
2jan		Tyrosyl-trna synthetase from mycobacterium tuberculosis in unliganded state
2k6p		Solution structure of hypothetical protein, hp1423
2ow8		Crystal structure of a 70s ribosome-trna complex reveals functional interactions and rearrangements. this file, 2ow8, contains the 30s ribosome subunit, two trna, and mrna molecules. 50s ribosome subunit is in the file 1vsa.
2qal		Crystal structure of the bacterial ribosome from escherichia coli in complex with neomycin. this file contains the 30s subunit of the first 70s ribosome, with neomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2qan		Crystal structure of the bacterial ribosome from escherichia coli in complex with neomycin. this file contains the 30s subunit of the second 70s ribosome, with neomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2qb9		Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin. this file contains the 30s subunit of the first 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2qbb		Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin. this file contains the 30s subunit of the second 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2qbd		Crystal structure of the bacterial ribosome from escherichia coli in complex with ribosome recycling factor (rrf). this file contains the 30s subunit of the first 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2qbf		Crystal structure of the bacterial ribosome from escherichia coli in complex with ribosome recycling factor (rrf). this file contains the 30s subunit of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2qbh		Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin and ribosome recycling factor (rrf). this file contains the 30s subunit of the first 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2qbj		Crystal structure of the bacterial ribosome from escherichia coli in complex with gentamicin and ribosome recycling factor (rrf). this file contains the 30s subunit of the second 70s ribosome, with gentamicin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2qnh		Interactions and dynamics of the shine-dalgarno helix in the 70s ribosome. this file, 2qnh, contains the 30s ribosome subunit, two trna, and mrna molecules. 50s ribosome subunit is in the file 1vsp.
2qou		Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin. this file contains the 30s subunit of the first 70s ribosome, with spectinomycin bound. the entire crystal structure contains two 70s ribosomes.
2qow		Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin. this file contains the 30s subunit of the second 70s ribosome, with spectinomycin bound. the entire crystal structure contains two 70s ribosomes.
2qoy		Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin and neomycin. this file contains the 30s subunit of the first 70s ribosome, with spectinomycin and neomycin bound. the entire crystal structure contains two 70s ribosomes.
2qp0		Crystal structure of the bacterial ribosome from escherichia coli in complex with spectinomycin and neomycin. this file contains the 30s subunit of the second 70s ribosome, with spectinomycin and neomycin bound. the entire crystal structure contains two 70s ribosomes.
2ts1		Structure of tyrosyl-t/rna synthetase refined at 2.3 angstroms resolution. interaction of the enzyme with the tyrosyl adenylate intermediate
2uu9		Structure of the thermus thermophilus 30s ribosomal subunit complexed with a valine-asl with cmo5u in position 34 bound to an mrna with a gug-codon in the a-site and paromomycin.
2uua		Structure of the thermus thermophilus 30s ribosomal subunit complexed with a valine-asl with cmo5u in position 34 bound to an mrna with a guc-codon in the a-site and paromomycin.
2uub		Structure of the thermus thermophilus 30s ribosomal subunit complexed with a valine-asl with cmo5u in position 34 bound to an mrna with a guu-codon in the a-site and paromomycin.
2uuc		Structure of the thermus thermophilus 30s ribosomal subunit complexed with a valine-asl with cmo5u in position 34 bound to an mrna with a gua-codon in the a-site and paromomycin.
2uxb		Crystal structure of an extended trna anticodon stem loop in complex with its cognate mrna gggu in the context of the thermus thermophilus 30s subunit.
2uxc		Crystal structure of an extended trna anticodon stem loop in complex with its cognate mrna ucgu in the context of the thermus thermophilus 30s subunit.
2uxd		Crystal structure of an extended trna anticodon stem loop in complex with its cognate mrna cggg in the context of the thermus thermophilus 30s subunit.
2v46		Structure of the ribosome recycling factor bound to the thermus thermophilus 70s ribosome with mrna, asl-phe and trna-fmet (part 1 of 4). this file contains the 30s subunit, mrna, p-site asl, e-site trna and rrf for molecule 1.
2v48		Structure of the ribosome recycling factor bound to the thermus thermophilus 70s ribosome with mrna, asl-phe and trna-fmet (part 3 of 4). this file contains the 30s subunit, mrna, p-site asl, e-site trna and rrf for molecule 2.
2vho		Structure of pdf binding helix in complex with the ribosome (part 3 of 4)
2vhp		Structure of pdf binding helix in complex with the ribosome (part 4 of 4)
2vqe		Modified uridines with c5-methylene substituents at the first position of the trna anticodon stabilize u-g wobble pairing during decoding
2vqf		Modified uridines with c5-methylene substituents at the first position of the trna anticodon stabilize u-g wobble pairing during decoding
2wdg		Structure of the thermus thermophilus 70s ribosome in complex with mrna, paromomycin, acylated a-site trna, deacylated p-site trna, and e-site trna. this file contains the 30s subunit a-,p-, and e-site trnas and paromomycin for molecule i.
2wdh		Structure of the thermus thermophilus 70s ribosome in complex with mrna, paromomycin, acylated a-site trna, deacylated p-site trna, and e-site trna. this file contains the 30s subunit a-,p-, and e-site trnas and paromomycin for molecule ii.
2wdk		Structure of the thermus thermophilus 70s ribosome in complex with mrna, paromomycin, acylated a- and p-site trnas, and e-site trna. this file contains the 30s subunit a-,p-, and e-site trnas and paromomycin for molecule i.
2wdm		Structure of the thermus thermophilus 70s ribosome in complex with mrna, paromomycin, acylated a- and p-site trnas, and e-site trna. this file contains the 30s subunit a-,p-, and e-site trnas and paromomycin for molecule ii.
2wh1		Insights into translational termination from the structure of rf2 bound to the ribosome
2wh3		Insights into translational termination from the structure of rf2 bound to the ribosome). this file contains the 30s subunit.
2wri		The structure of the ribosome with elongation factor g trapped in the post-translocational state (part 1 of 4).
2wrk		The structure of the ribosome with elongation factor g trapped in the post-translocational state (part 3 of 4).
2wrn		The crystal structure of the 70s ribosome bound to ef-tu and trna (part 1 of 4).
2wrq		The crystal structure of the 70s ribosome bound to ef-tu and trna (part 3 of 4).
2z4k		Crystal structure of the bacterial ribosome from escherichia coli in complex with paromomycin and ribosome recycling factor (rrf). this file contains the 30s subunit of the first 70s ribosome, with paromomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2z4m		Crystal structure of the bacterial ribosome from escherichia coli in complex with paromomycin and ribosome recycling factor (rrf). this file contains the 30s subunit of the second 70s ribosome, with paromomycin bound. the entire crystal structure contains two 70s ribosomes and is described in remark 400.
2zkq		Structure of a mammalian ribosomal 40s subunit within an 80s complex obtained by docking homology models of the rna and proteins into an 8.7 a cryo-em map
2zm6		Crystal structure of the thermus thermophilus 30s ribosomal subunit
3bbn		Homology model for the spinach chloroplast 30s subunit fitted to 9.4a cryo-em map of the 70s chlororibosome.
3bbu		The hsp15 protein fitted into the low resolution cryo-em map of the 50s.nc-trna.hsp15 complex
3d5a		Structural basis for translation termination on the 70s ribosome. this file contains the 30s subunit, release factor 1 (rf1), two trna, and mrna molecules of one 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400.
3d5c		Structural basis for translation termination on the 70s ribosome. this file contains the 30s subunit, release factor 1 (rf1), two trna, and mrna molecules of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400.
3df1		Crystal structure of the bacterial ribosome from escherichia coli in complex with hygromycin b. this file contains the 30s subunit of the first 70s ribosome, with hygromycin b bound. the entire crystal structure contains two 70s ribosomes.
3df3		Crystal structure of the bacterial ribosome from escherichia coli in complex with hygromycin b. this file contains the 30s subunit of the second 70s ribosome, with hygromycin b bound. the entire crystal structure contains two 70s ribosomes.
3dh3		Crystal structure of rluf in complex with a 22 nucleotide rna substrate
3e1a		Structure of the 30s subunit and the trnas of e. coli ribosome in pre-accommodation state
3e1c		Structure of the 30s subunit and the trnas of e. coli ribosome in post-accommodation state
3f1e		Crystal structure of a translation termination complex formed with release factor rf2. this file contains the 30s subunit, rf2, two trna, and mrna molecules of one 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400.
3f1g		Crystal structure of a translation termination complex formed with release factor rf2. this file contains the 30s subunit, rf2, two trna, and mrna molecules of the second 70s ribosome. the entire crystal structure contains two 70s ribosomes as described in remark 400.
3fic		T. thermophilus 70s ribosome in complex with mrna, trnas and ef-tu.gdp.kirromycin ternary complex, fitted to a 6.4 a cryo-em map. this file contains the 30s subunit and the ligands
3fih		Ternary complex-bound e.coli 70s ribosome. this entry consists of the 30s subunit, trnas and the ternary complex.
3hp7		Putative hemolysin from streptococcus thermophilus.
3huw		Structure of ef-p bound to the 70s ribosome; this file contains the 30s subunit, mrna, p-site trna and ef-p for molecule i.
3huy		Structure of ef-p bound to the 70s ribosome; this file contains the 30s subunit, mrna, p-site trna and ef-p for molecule ii.
3i1m		Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting
3i1o		Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting
3i1q		Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting
3i1s		Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting
3i1z		Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting
3i21		Crystal structure of the e. coli 70s ribosome in an intermediate state of ratcheting
3kbg		Crystal structure of the 30s ribosomal protein s4e from thermoplasma acidophilum. northeast structural genomics consortium target tar28.
3ts1		Structure of tyrosyl-t/rna synthetase refined at 2.3 angstroms resolution. interaction of the enzyme with the tyrosyl adenylate intermediate

Links (links to other resources describing this domain)
PFAM S4
INTERPRO IPR002942
PROSITE RIBOSOMAL_S4

PFAM	S4
INTERPRO	IPR002942
PROSITE	RIBOSOMAL_S4