DNA binding domain with preference for A/T rich regions
SMART accession number:SM00384
Description: Small DNA-binding motif first described in the high mobility group non-histone chromosomal protein HMG-I(Y).
Interpro abstract (IPR017956):

AT hooks are DNA-binding motifs with a preference for A/T rich regions. These motifs are found in a variety of proteins, including the high mobility group (HMG) proteins [(PUBMED:11406267)], in DNA-binding proteins from plants [(PUBMED:8790293)] and in hBRG1 protein, a central ATPase of the human switching/sucrose non-fermenting (SWI/SNF) remodeling complex [(PUBMED:17081121)].

High mobility group (HMG) proteins are a family of relatively low molecular weight non-histone components in chromatin [(PUBMED:11406267)]. HMG-I and HMG-Y (HMGA) are proteins of about 100 amino acid residues which are produced by the alternative splicing of a single gene. HMG-I/Y proteins bind preferentially to the minor groove of AT-rich regions in double-stranded DNA in a non-sequence specific manner [(PUBMED:1692833), (PUBMED:8414980)]. It is suggested that these proteins could function in nucleosome phasing and in the 3' end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to, AT-rich regions.

GO function:DNA binding (GO:0003677)
Family alignment:
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There are 6290 AT_hook domains in 3446 proteins in SMART's nrdb database.

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