SMART accession number:SM00392
Description: Binds actin monomers, membrane polyphosphoinositides and poly-L-proline.
Interpro abstract (IPR005455):

Profilin is a small eukaryotic protein that binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filaments (F-actin). It can also in certain circumstance promote actin polymerisation. Profilin also binds to polyphosphoinositides such as PIP2 [(PUBMED:11034907)]. Overall sequence similarity among profilin from organisms which belong to different phyla (ranging from fungi to mammals) is low, but the N-terminal region is relatively well conserved. That region is thought to be involved in the binding to actin.

Profilin is the major allergen present in pollens [(PUBMED:21458043)].

GO process:actin cytoskeleton organization (GO:0030036)
GO function:actin binding (GO:0003779)
Family alignment:
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There are 679 PROF domains in 616 proteins in SMART's nrdb database.

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