Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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PSI domain found in Plexins, Semaphorins and Integrins

SMART accession number:	SM00423
Description:
Interpro abstract (IPR003659):	This is a domain that has been found in plexins, semaphorins and integrins. Plexin is involved in the development of neural and epithelial tissues; semaphorins induce the collapse and paralysis of neuronal growth cones; and integrins may mediate adhesive or migratory functions of epithelial cells.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 3043 PSI domains in 2002 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a PSI domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with PSI domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Disease (disease genes where sequence variants are found in this domain)

• SwissProt sequences and OMIM curated human diseases associated with missense mutations within the PSI domain.

  Protein	Disease
  Integrin beta-3 (P05106) (SMART)	OMIM:173470: Glanzmann thrombasthenia, type B
  Integrin beta-4 (P16144) (SMART)	OMIM:147557: Epidermolysis bullosa, junctional, with pyloric atresia OMIM:226730: Epidermolysis bullosa, generalized atrophic benign OMIM:226650:

• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 38.12 map04360 Axon guidance 12.71 map04510 Focal adhesion 12.50 map04810 Regulation of actin cytoskeleton 10.83 map04512 ECM-receptor interaction 6.04 map04514 Cell adhesion molecules (CAMs) 3.54 map04670 Leukocyte transendothelial migration 1.88 map04520 Adherens junction 1.88 map05222 Small cell lung cancer 1.88 map05120 Epithelial cell signaling in Helicobacter pylori infection 1.88 map05210 Colorectal cancer 1.88 map04060 Cytokine-cytokine receptor interaction 1.88 map05211 Renal cell carcinoma 1.88 map05218 Melanoma 1.67 map04650 Natural killer cell mediated cytotoxicity 1.46 map04640 Hematopoietic cell lineage This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PSI domain which could be assigned to a KEGG orthologous group, and not all proteins containing PSI domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of PSI domains in PDB

  PDB code	Main view	Title
  1jv2		Crystal structure of the extracellular segment of integrin alphavbeta3
  1l5g		Crystal structure of the extracellular segment of integrin avb3 in complex with an arg-gly-asp ligand
  1m1x		Crystal structure of the extracellular segment of integrin alpha vbeta3 bound to mn2+
  1olz		The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of sema4d
  1shy		The crystal structure of hgf beta-chain in complex with the sema domain of the met receptor.
  1ssl		Solution structure of the psi domain from the met receptor
  1tye		Structural basis for allostery in integrins and binding of ligand-mimetic therapeutics to the platelet receptor for fibrinogen
  1u8c		A novel adaptation of the integrin psi domain revealed from its crystal structure
  1yuk		The crystal structure of the psi/hybrid domain/ i-egf1 segment from the human integrin beta2 at 1.8 resolution
  2p26		Structure of the phe2 and phe3 fragments of the integrin beta2 subunit
  2p28		Structure of the phe2 and phe3 fragments of the integrin beta2 subunit
  2uzx		Structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i
  2uzy		Structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: low resolution, crystal form ii
  2vc2		Re-refinement of integrin alphaiibbeta3 headpiece bound to antagonist l-739758
  2vdk		Re-refinement of integrin alphaiibbeta3 headpiece
  2vdl		Re-refinement of integrin alphaiibbeta3 headpiece
  2vdm		Re-refinement of integrin alphaiibbeta3 headpiece bound to antagonist tirofiban
  2vdn		Re-refinement of integrin alphaiibbeta3 headpiece bound to antagonist eptifibatide
  2vdo		Integrin alphaiibbeta3 headpiece bound to fibrinogen gamma chain peptide, hhlggakqagdv
  2vdp		Integrin alphaiibbeta3 headpiece bound to fibrinogen gamma chain peptide,lggakqagdv
  2vdq		Integrin alphaiibbeta3 headpiece bound to a chimeric fibrinogen gamma chain peptide, hhlggakqrgdv
  2vdr		Integrin alphaiibbeta3 headpiece bound to a chimeric fibrinogen gamma chain peptide, lggakqrgdv
  3fcs		Structure of complete ectodomain of integrin aiibb3
  3fcu		Structure of headpiece of integrin aiibb3 in open conformation
  3ije		Crystal structure of the complete integrin alhavbeta3 ectodomain plus an alpha/beta transmembrane fragment

• Links (links to other resources describing this domain)

• INTERPRO	IPR003659

Send comments to Ivica Letunic