SMART: IPT domain annotation

IPT ig-like, plexins, transcription factors

SMART accession number:	SM00429
Description:
Interpro abstract (IPR002909):	This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. The Ron tyrosine kinase receptor shares with the members of its subfamily (Met and Sea) a unique functional feature: the control of cell dissociation, motility, and invasion of extracellular matrices (scattering) [(PUBMED:8816464)].
GO function:	protein binding (GO:0005515)
Family alignment:	View or

There are 3673 IPT domains in 1384 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with IPT domain is also avaliable.

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Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Aravind L, Koonin EV
- Gleaning non-trivial structural, functional and evolutionary information about proteins by iterative database searches.
- J Mol Biol. 1999; 287: 1023-40
- Display abstract
- Using a number of diverse protein families as test cases, we investigate the ability of the recently developed iterative sequence database search method, PSI-BLAST, to identify subtle relationships between proteins that originally have been deemed detectable only at the level of structure-structure comparison. We show that PSI-BLAST can detect many, though not all, of such relationships, but the success critically depends on the optimal choice of the query sequence used to initiate the search. Generally, there is a correlation between the diversity of the sequences detected in the first pass of database screening and the ability of a given query to detect subtle relationships in subsequent iterations. Accordingly, a thorough analysis of protein superfamilies at the sequence level is necessary in order to maximize the chances of gleaning non-trivial structural and functional inferences, as opposed to a single search, initiated, for example, with the sequence of a protein whose structure is available. This strategy is illustrated by several findings, each of which involves an unexpected structural prediction: (i) a number of previously undetected proteins with the HSP70-actin fold are identified, including a highly conserved and nearly ubiquitous family of metal-dependent proteases (typified by bacterial O-sialoglycoprotease) that represent an adaptation of this fold to a new type of enzymatic activity; (ii) we show that, contrary to the previous conclusions, ATP-dependent and NAD-dependent DNA ligases are confidently predicted to possess the same fold; (iii) the C-terminal domain of 3-phosphoglycerate dehydrogenase, which binds serine and is involved in allosteric regulation of the enzyme activity, is shown to typify a new superfamily of ligand-binding, regulatory domains found primarily in enzymes and regulators of amino acid and purine metabolism; (iv) the immunoglobulin-like DNA-binding domain previously identified in the structures of transcription factors NFkappaB and NFAT is shown to be a member of a distinct superfamily of intracellular and extracellular domains with the immunoglobulin fold; and (v) the Rag-2 subunit of the V-D-J recombinase is shown to contain a kelch-type beta-propeller domain which rules out its evolutionary relationship with bacterial transposases.
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

3D Structures of IPT domains in PDB

PDB code	Main view	Title
1a02		Structure of the dna binding domains of nfat, fos and jun bound to dna
1a3q		Human nf-kappa-b p52 bound to dna
1bfs		Structure of nf-kb p50 homodimer bound to a kb site
1bft		Structure of nf-kb p50 homodimer bound to a kb site
1gji		Crystal structure of c-rel bound to dna
1ikn		Ikappabalpha/nf-kappab complex
1imh		Tonebp/dna complex
1k3z		X-ray crystal structure of the ikbb/nf-kb p65 homodimer complex
1le5		Crystal structure of a nf-kb heterodimer bound to an ifnb-kb
1le9		Crystal structure of a nf-kb heterodimer bound to the ig/hiv-kb siti
1lei		The kb dna sequence from the hlv-ltr functions as an allosteric regulator of hiv transcription
1my5		Nf-kappab p65 subunit dimerization domain homodimer
1my7		Nf-kappab p65 subunit dimerization domain homodimer n202r mutation
1nfi		I-kappa-b-alpha/nf-kappa-b complex
1nfk		Structure of the nuclear factor kappa-b (nf-kb) p50 homodimer
1ooa		Crystal structure of nf-kb(p50)2 complexed to a high- affinity rna aptamer
1owr		Crystal structure of human nfat1 bound monomerically to dna
1oy3		Crystal structure of an ikbbeta/nf-kb p65 homodimer complex
1p7h		Structure of nfat1 bound as a dimer to the hiv-1 ltr kb element
1pzu		An asymmetric nfat1-rhr homodimer on a pseudo-palindromic, kappa-b site
1qho		Five-domain alpha-amylase from bacillus stearothermophilus, maltose/acarbose complex
1qhp		Five-domain alpha-amylase from bacillus stearothermophilus, maltose complex
1ram		A novel dna recognition mode by nf-kb p65 homodimer
1s9k		Crystal structure of human nfat1 and fos-jun on the il-2 arre1 site
1svc		Nfkb p50 homodimer bound to dna
1u36		Crystal stucture of wlac mutant of dimerisation domain of nf-kb p50 transcription factor
1u3j		Crystal stucture of mlav mutant of dimerisation domain of nf-kb p50 transcription factor
1u3y		Crystal stucture of ilac mutant of dimerisation domain of nf-kb p50 transcription factor
1u3z		Crystal stucture of mlac mutant of dimerisation domain of nf-kb p50 transcription factor
1u41		Crystal stucture of ylgv mutant of dimerisation domain of nf-kb p50 transcription factor
1u42		Crystal stucture of mlam mutant of dimerisation domain of nf-kb p50 transcription factor
1vkx		Crystal structure of the nfkb p50/p65 heterodimer complexed to the immunoglobulin kb dna
1zk9		Nf-kb relb forms an intertwined homodimer
1zka		Nf-kb relb forms an intertwined homodimer, y300s mutant
2as5		Structure of the dna binding domains of nfat and foxp2 bound specifically to dna.
2i9t		Structure of nf-kb p65-p50 heterodimer bound to prdii element of b-interferon promoter
2o61		Crystal structure of nfkb, irf7, irf3 bound to the interferon-b enhancer
2o93		Crystal structure of nfat bound to the hiv-1 ltr tandem kappab enhancer element
2ram		A novel dna recognition mode by nf-kb p65 homodimer
2uzx		Structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: crystal form i
2uzy		Structure of the human receptor tyrosine kinase met in complex with the listeria monocytogenes invasion protein inlb: low resolution, crystal form ii
2v2t		X-ray structure of a nf-kb p50-relb-dna complex
2yrp		Solution structure of the tig domain from human nuclear factor of activated t-cells, cytoplasmic 4
3do7		X-ray structure of a nf-kb p52/relb/dna complex
3gut		Crystal structure of a higher-order complex of p50:rela bound to the hiv-1 ltr

Links (links to other resources describing this domain)
INTERPRO IPR002909