Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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FF Contains two conserved F residues

SMART accession number:	SM00441
Description:	A novel motif that often accompanies WW domains. Often contains two conserved Phe (F) residues.
Interpro abstract (IPR002713):	The FF domain may be involved in protein-protein interaction [(PUBMED:10390614)]. It often occurs as multiple copies and often accompanies WW domains IPR001202. PRP40 from yeast encodes a novel, essential splicing component that associates with the yeast U1 small nuclear ribonucleoprotein particle [(PUBMED:8622699)].
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 1512 FF domains in 363 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a FF domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with FF domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Bedford MT, Leder P
  • The FF domain: a novel motif that often accompanies WW domains.
  • Trends Biochem Sci. 1999; 24: 264-5
• Metabolism (metabolic pathways involving proteins which contain this domain)

• % proteins involved KEGG pathway ID Description 50.00 map04510 Focal adhesion 50.00 map04670 Leukocyte transendothelial migration This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with FF domain which could be assigned to a KEGG orthologous group, and not all proteins containing FF domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of FF domains in PDB

  PDB code	Main view	Title
  1uzc		The structure of an ff domain from human hypa/fbp11
  2b7e		First ff domain of prp40 yeast protein
  2cqn		Solution structure of the ff domain of human formin-binding protein 3
  2dod		Solution structure of the first ff domain of human transcription factor ca150
  2doe		Solution structure of the third ff domain of human transcription factor ca150
  2dof		Solution structure of the fourth ff domain of human transcription factor ca150
  2e71		Solution structure of the second ff domain of human transcription factor ca150
  2juc		Urn1 ff domain yeast
  2k85		P190-a rhogap ff1 domain
  2kfd		Prp40 ff4 domain
  2kiq		Solution structure of the ff domain 2 of human transcription elongation factor ca150
  2kis		Solution structure of ca150 ff1 domain and ff1-ff2 interdomain linker
  3hfh		Crystal structure of tandem ff domains

• Links (links to other resources describing this domain)

• INTERPRO	IPR002713

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