LINK

Link (Hyaluronan-binding)
LINK
SMART accession number:SM00445
Description:
Interpro abstract (IPR000538): The link domain [(PUBMED:8318021)] is a hyaluronan(HA)-binding region found in proteins of vertebrates that are involved in the assembly of extracellular matrix, cell adhesion, and migration. The structure has been shown [(PUBMED:8797823)] to consist of two alpha helices and two antiparallel beta sheets arranged around a large hydrophobic core similar to that of C-type lectin. This domain contains four conserved cysteines involved in two disulphide bonds. The link domain has also been termed HABM [(PUBMED:8318021)] (HA binding module) and PTR [(PUBMED:8690089)] (proteoglycan tandem repeat). Proteins with such a domain include the proteoglycans aggrecan, brevican, neurocan and versican, which are expressed in the CNS; the cartilage link protein (LP), a proteoglycan that together with HA and aggrecan forms multimolecular aggregates; Tumour necrosis factor-inducible protein TSG-6, which may be involved in cell-cell and cell-matrix interactions during inflammation and tumourgenesis; and CD44 antigen, the main cell surface receptor for HA.
GO process:cell adhesion (GO:0007155)
GO function:hyaluronic acid binding (GO:0005540)
Family alignment:
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There are 1016 LINK domains in 595 proteins in SMART's nrdb database.

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