LRRcap

occurring C-terminal to leucine-rich repeats
LRRcap
SMART accession number:SM00446
Description: A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.
Interpro abstract (IPR003603):

This motif occurs C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins. Examples from the metazoa are described as either "Acidic leucine-rich nuclear phosphoprotein 32 family member A" or have been characterised as U2A', the protein that interacts with U2B'' facilitating the interaction with U2 snRNA. U2A' is required for the spliceosome assembly and the efficient addition of U2 snRNP onto the pre-mRNA [(PUBMED:9799242)]. The crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA has been described [(PUBMED:9716128)].

Family alignment:
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There are 3078 LRRcap domains in 2711 proteins in SMART's nrdb database.

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