Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
SMART accession number:SM00462
Description: PTB/PI domain structure similar to those of pleckstrin homology (PH) and IRS-1-like PTB domains.
Interpro abstract (IPR006020):

The PI domain has a similar structure to the insulin receptor substrate-1 PTB domain, a 7-stranded beta-sandwich, capped by a C-terminal helix. However, the PI domain contains an additional short N-terminal helix and a large insertion between strands 1 and 2, which forms a helix and 2 long connecting loops. The substrate peptide fits into a surface cleft formed from the C-terminal helix and strand 5 [(PUBMED:8599766)].

GO function:protein binding (GO:0005515)
Family alignment:
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There are 1493 PTB domains in 1314 proteins in SMART's nrdb database.

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