GIY-YIG type nucleases (URI domain)
SMART accession number:SM00465
Interpro abstract (IPR000305):

During the process of Escherichia coli nucleotide excision repair, DNA damage recognition and processing are achieved by the action of the uvrA, uvrB, and uvrC gene products [(PUBMED:12034838)]. The UvrC proteins contain 4 conserved regions: a domain which interacts with UvrB (Uvr domain), a Helix hairpin Helix (HhH) domain important for 5 prime incision of damage DNA and the homology regions 1 and 2 of unknown function. UvrC homology region 2 is specific for UvrC proteins, whereas UvrC homology region 1 is also shared by few other nucleases.

The homology region 1 is found in the amino terminal region of excinuclease abc subunit c (uvrC), Bacteriophage T4 endonucleases segA, segB, segC, segD and segE; it is also found in putative endonucleases encoded by group I introns of fungi and phage.

Family alignment:
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There are 2617 GIYc domains in 2617 proteins in SMART's nrdb database.

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