Metal dependent phosphohydrolases with conserved 'HD' motif.
SMART accession number:SM00471
Description: Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).
Interpro abstract (IPR003607): This entry represents the HD domain, which is is found in a superfamily of enzymes with a predicted or known phosphohydrolase activity. It also represents a related phosphodiesterase (PDEase) domain that is found in eukaryotic 3',5'-cGMP phosphodiesterase (EC, which is located in photoreceptor outer segments and it is light activated, playing a pivotal role in signal transduction.
Family alignment:
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There are 209505 HDc domains in 208022 proteins in SMART's nrdb database.

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