DNA/RNA non-specific endonuclease
SMART accession number:SM00477
Description: prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases
Interpro abstract (IPR020821):

A family of bacterial and eukaryotic endonucleases EC 3.1.30 share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. A histidine has been shown [ (PUBMED:8078761) ] to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.

GO function:nucleic acid binding (GO:0003676), hydrolase activity (GO:0016787), metal ion binding (GO:0046872)
Family alignment:
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There are 11868 NUC domains in 11849 proteins in SMART's nrdb database.

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