NUCDNA/RNA non-specific endonuclease
|SMART accession number:||SM00477
||prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases|
|Interpro abstract (IPR020821):
||A family of bacterial and eukaryotic endonucleases EC 3.1.30 share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. A histidine has been shown [(PUBMED:8078761)] to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.
|GO function:||hydrolase activity (GO:0016787), metal ion binding (GO:0046872), nucleic acid binding (GO:0003676)|
There are 3516 NUC domains in 3505 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
- Literature (relevant references for this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
- Links (links to other resources describing this domain)