Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2008) Nucleic Acids Res , doi:10.1093/nar/gkn808

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HELICc helicase superfamily c-terminal domain

There are 18056 HELICc domains in 17937 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a HELICc domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with HELICc domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Bork P, Koonin EV
  • An expanding family of helicases within the 'DEAD/H' superfamily.
  • Nucleic Acids Res. 1993; 21: 751-2
• Disease (disease genes where sequence variants are found in this domain)

• SwissProt sequences and OMIM curated human diseases associated with missense mutations within the HELICc domain.

  Protein	Disease
  Transcriptional regulator ATRX (SRS)(SMART)	OMIM:300032: Alpha-thalassemia/mental retardation syndrome OMIM:301040: Juberg-Marsidi syndrome OMIM:309590: Sutherland-Haan syndrome OMIM:309470: Smith-Fineman-Myers syndrome OMIM:309580:

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 42.40 map00500 Starch and sucrose metabolism 42.40 map00790 Folate biosynthesis 8.69 map00230 Purine metabolism 5.69 map03090 Type II secretion system 0.52 map04310 Wnt signaling pathway 0.10 map00970 Aminoacyl-tRNA biosynthesis 0.10 map03020 RNA polymerase 0.10 map00330 Arginine and proline metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with HELICc domain which could be assigned to a KEGG orthologous group, and not all proteins containing HELICc domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of HELICc domains in PDB

  PDB code	Main view	Title
  1c4o		Crystal structure of the dna nucleotide excision repair enzyme uvrb from thermus thermophilus
  1d2m		Uvrb protein of thermus thermophilus hb8; a nucleotide excision repair enzyme
  1d9x		Crystal structure of the dna repair protein uvrb
  1d9z		Crystal structure of the dna repair protein uvrb in complex with atp
  1fuk		Crystal structure of the carboxy terminal domain of yeast eif4a
  1fuu		Yeast initiation factor 4a
  1gm5		Structure of recg bound to three-way dna junction
  1hv8		Crystal structure of a dead box protein from the hyperthermophile methanococcus jannaschii
  1jr6		Solution structure of an engineered arginine-rich subdomain of the hepatitis c virus ns3 rna helicase
  1onb		Solution structure of an engineered arginine-rich subdomain of the hepatitis c virus ns3 rna helicase
  1oyw		Structure of the recq catalytic core
  1oyy		Structure of the recq catalytic core bound to atp-gamma-s
  1s2m		Crystal structure of the dead box protein dhh1p
  1t5i		Crystal structure of the c-terminal domain of uap56
  1t5l		Crystal structure of the dna repair protein uvrb point mutant y96a revealing a novel fold for domain 2
  1wp9		Crystal structure of pyrococcus furiosus hef helicase domain
  1xti		Structure of wildtype human uap56
  1xtj		Structure of human uap56 in complex with adp
  1xtk		Structure of decd to dead mutation of human uap56
  1yks		Crystal structure of yellow fever virus ns3 helicase
  1ymf		Crystal structure of yellow fever virus ns3 helicase complexed with adp
  1z3i		Structure of the swi2/snf2 chromatin remodeling domain of eukaryotic rad54
  1z5z		Sulfolobus solfataricus swi2/snf2 atpase c-terminal domain
  1z63		Sulfolobus solfataricus swi2/snf2 atpase core in complex with dsdna
  1z6a		Sulfolobus solfataricus swi2/snf2 atpase core domain
  2bhr		Dengue virus rna helicase
  2bmf		Dengue virus rna helicase at 2.4a
  2d7d		Structural insights into the cryptic dna dependent atp-ase activity of uvrb
  2db3		Structural basis for rna unwinding by the dead-box protein drosophila vasa
  2eyq		Crystal structure of escherichia coli transcription-repair coupling factor
  2fdc		Structural basis of dna damage recognition and processing by uvrb: crystal structure of a uvrb/dna complex
  2fwr		Structure of archaeoglobus fulgidis xpb
  2fzl		Structure of c-terminal domain of archaeoglobus fulgidus xpb
  2hjv		Structure of the second domain (residues 207-368) of the bacillus subtilis yxin protein
  2hxy		Crystal structure of human apo-eif4aiii
  2hyi		Structure of the human exon junction complex with a trapped dead-box helicase bound to rna
  2i4i		Crystal structure of human dead-box rna helicase ddx3x
  2j0q		The crystal structure of the exon junction complex at 3.2 a resolution
  2j0s		The crystal structure of the exon junction complex at 2.2 a resolution
  2j0u		The crystal structure of eif4aiii-barentsz complex at 3.0 a resolution
  2jgn		Ddx3 helicase domain
  2kbf
  2nmv		Damage detection by the uvrabc pathway: crystal structure of uvrb bound to fluorescein-adducted dna
  2oca		The crystal structure of t4 uvsw
  2p6n		Human dead-box rna helicase ddx41, helicase domain
  2p6r		Crystal structure of superfamily 2 helicase hel308 in complex with unwound dna
  2p6u		Apo structure of the hel308 superfamily 2 helicase
  2qeq		Crystal structure of kunjin virus ns3 helicase
  2rb4		Crystal structure of the helicase domain of human ddx25 rna helicase
  2v1x		Crystal structure of human recq-like dna helicase
  2v6i		Kokobera virus helicase
  2v6j		Kokobera virus helicase: mutant met47thr
  2v8o		Structure of the murray valley encephalitis virus rna helicase to 1.9a resolution
  2va8		Dna repair helicase hel308
  2vso		Crystal structure of a translation initiation complex
  2vsx		Crystal structure of a translation initiation complex
  2wax
  2way
  2z0m		Crystal structure of hypothetical atp-dependent rna helicase from sulfolobus tokodaii
  2z83		Crystal structure of catalytic domain of japanese encephalitis virus ns3 helicase/nucleoside triphosphatase at a resolution 1.8
  2zj2
  2zj5
  2zj8
  2zja
  2zu6
  3dmq
  3eaq
  3ear
  3eas
  3eiq
  3ews
  3ex7
  3fho
  3fht
  3fmp
  3g0h
  3gfp
  3i32
  3i5x
  3i5y
  3i61
  3i62

• Links (links to other resources describing this domain)

• PFAM	helicase_C
  INTERPRO	IPR001650