BRIGHTBRIGHT, ARID (A/T-rich interaction domain) domain
|SMART accession number:||SM00501|
|Description:||DNA-binding domain containing a helix-turn-helix structure|
|Interpro abstract (IPR001606):|
The AT-rich interaction domain (ARID) is an ~100-amino acid DNA-binding module found in a large number of eukaryotic transcription factors that regulate cell proliferation, differentiation and development [(PUBMED:10545119), (PUBMED:11867548)]. The ARID domain appears as a single-copy motif and can be found in association with other domains, such as JmjC, JmjN, Tudor and PHD-type zinc finger [(PUBMED:11959810)].
The basic structure of the ARID domain domain appears to be a series of six alpha-helices separated by beta-strands, loops, or turns, but the structured region may extend to an additional helix at either or both ends of the basic six. Based on primary sequence homology, they can be partitioned into three structural classes:
Minimal ARIDs are distributed in all eukaryotes, while extended ARIDs are restricted to metazoans. The ARID domain binds DNA as a monomer, recognizing the duplex through insertion of a loop and an alpha-helix into the major groove, and by extensive non-specific anchoring contacts to the adjacent sugar-phosphate backbone [(PUBMED:10545119), (PUBMED:11867548), (PUBMED:14722072)].
Some proteins known to contain a ARID domain are listed below:
|GO function:||DNA binding (GO:0003677)|
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- Evolution (species in which this domain is found)
- Literature (relevant references for this domain)
- Structure (3D structures containing this domain)
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