SynNSyntaxin N-terminal domain
|SMART accession number:||SM00503|
|Description:||Three-helix domain that (in Sso1p) slows the rate of its reaction with the SNAP-25 homologue Sec9p|
|Interpro abstract (IPR006011):|
Syntaxins are the prototype family of SNARE proteins. They usually consist of three main regions - a C-terminal transmembrane region, a central SNARE domain which is characteristic of and conserved in all syntaxins and an N-terminal domain that is featured in this entry. This domain varies between syntaxin isoforms; in syntaxin 1A (O35526) it is found as three alpha-helices with a left-handed twist. It may fold back on the SNARE domain to allow the molecule to adopt a 'closed' configuration that prevents formation of the core fusion complex - it thus has an auto-inhibitory role.
The function of syntaxins is determined by their localisation. They are involved in neuronal exocytosis, ER-Golgi transport and Golgi-endosome transport, for example. They also interact with other proteins as well as those involved in SNARE complexes. These include vesicle coat proteins, Rab GTPases, and tethering factors [(PUBMED:11737951)].
|GO component:||membrane (GO:0016020)|
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- Evolution (species in which this domain is found)
- Literature (relevant references for this domain)
- Metabolism (metabolic pathways involving proteins which contain this domain)
- Structure (3D structures containing this domain)
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