Skp1

Found in Skp1 protein family
Skp1
SMART accession number:SM00512
Description: Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.
Interpro abstract (IPR001232):

SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex [(PUBMED:10205047)]. It was found to bind several F-box containing proteins (e.g., Cdc4, Skp2, cyclin F) and to be involved in the ubiquitin protein degradation pathway. A yeast homologue of SKP1 (P52286) was identified in the centromere bound kinetochore complex [(PUBMED:8670864)] and is also involved in the ubiquitin pathway [(PUBMED:9390558)]. In Dictyostelium discoideum (Slime mold) FP21 was shown to be glycosylated in the cytosol and has homology to SKP1 [(PUBMED:7852383)].

GO process:ubiquitin-dependent protein catabolic process (GO:0006511)
Family alignment:
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There are 2796 Skp1 domains in 1518 proteins in SMART's nrdb database.

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