eIF5CDomain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5
|SMART accession number:||SM00515|
|Interpro abstract (IPR003307):|
Translation initiation is a sophisticated, well regulated and highly coordinated cellular process in eukaryotes, in which at least 11 eukayrotic initiation factors (eIFs) are included. The W2 domain (two invariant tryptophans) is a region of ~165 amino acids which is found in the C terminus of the following eIFs [(PUBMED:8520487), (PUBMED:10958635), (PUBMED:14681227), (PUBMED:16616930), (PUBMED:16781736)]:
The W2 domain has a globular fold and is exclusively composed out of alpha- helices [(PUBMED:14681227), (PUBMED:16616930), (PUBMED:16781736)]. The structure can be divided into a structural C-terminal core onto which the two N-terminal helices are attached. The core contains two aromatic/acidic residue-rich regions (AA boxes), which are important for mediating protein-protein interactions.
|GO function:||protein binding (GO:0005515)|
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