PolyA

C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein.
PolyA
SMART accession number:SM00517
Description: Involved in homodimerisation (either directly or indirectly)
Interpro abstract (IPR002004):

The polyadenylate-binding protein (PABP) has a conserved C-terminal domain (PABC), which is also found in the hyperplastic discs protein (HYD) family of ubiquitin ligases that contain HECT domains (IPR000569) [(PUBMED:11287654)]. PABP recognises the 3' mRNA poly(A) tail and plays an essential role in eukaryotic translation initiation and mRNA stabilisation/degradation. PABC domains of PABP are peptide-binding domains that mediate PABP homo-oligomerisation and protein-protein interactions. In mammals, the PABC domain of PABP functions to recruit several different translation factors to the mRNA poly(A) tail [(PUBMED:11940585)].

GO function:RNA binding (GO:0003723)
Family alignment:
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There are 390 PolyA domains in 378 proteins in SMART's nrdb database.

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