HMG17domain in high mobilty group proteins HMG14 and HMG 17
|SMART accession number:||SM00527|
|Interpro abstract (IPR000079):||This entry represents the HMGN family, whose members promote chromatin unfolding, enhance access to nucleosomes, and modulate transcription from chromatin templates. HMGNs are expressed only in vertebrates [(PUBMED:25281808)]. |
The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [(PUBMED:25281808)].
|GO component:||chromatin (GO:0000785), nucleus (GO:0005634)|
|GO function:||nucleosomal DNA binding (GO:0031492)|
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