Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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HNS Domain in histone-like proteins of HNS family

SMART accession number:	SM00528
Description:
Interpro abstract (IPR001801):	The histone-like nucleoid-structuring (H-NS) protein belongs to a family of bacterial proteins that play a role in the formation of nucleoid structure and affect gene expression under certain conditions [(PUBMED:7875316)].
GO process:	regulation of transcription, DNA-dependent (GO:0006355)
GO component:	intracellular (GO:0005622)
GO function:	DNA binding (GO:0003677)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 494 HNS domains in 470 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a HNS domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with HNS domain is also avaliable.

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• Cellular role (predicted cellular role)

• Binding / catalysis: DNA-binding

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Shindo H et al.
  • Solution structure of the DNA binding domain of a nucleoid-associated protein, H-NS, from Escherichia coli.
  • FEBS Lett. 1995; 360: 125-31
  • Display abstract

  • The three-dimensional structure of the C-terminal domain (47 residues) obtained from the hydrolysis of H-NS protein with bovine trypsin was determined by NMR measurements and distance geometry calculations. It is composed of an antiparallel beta-sheet, an alpha-helix and a 3(10)-helix which form a hydrophobic core, stabilizing the whole structure. This domain has been found to bind to DNA. Possible DNA binding sites are discussed on the basis of the solution structure of the C-terminal domain of H-NS.

• Structure (3D structures containing this domain)

• 3D Structures of HNS domains in PDB

  PDB code	Main view	Title
  1hnr		H-ns (dna-binding domain)
  1hns		H-ns (dna-binding domain)
  2jr1		Solution structure of the dna binding domain of a nucleoid- associated protein, h-ns, from the phytopathogen xylella fastidiosa.

• Links (links to other resources describing this domain)

• PFAM	Histone_HNS
  INTERPRO	IPR001801

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