LEM

in nuclear membrane-associated proteins
LEM
SMART accession number:SM00540
Description: LEM, domain in nuclear membrane-associated proteins, including lamino-associated polypeptide 2 and emerin.
Interpro abstract (IPR003887):

The LEM domain is found in nuclear membrane-associated proteins, including lamino-associated polypeptide 2 and emerin [(PUBMED:11792821)]. Defects in the emerin gene are a cause of Emery-Dreifuss muscular dystrophy, an X-linked disorder characterised by early contractures, muscle wasting, weakness and cardiomyopathy.

GO component:nuclear envelope (GO:0005635)
Family alignment:
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There are 149 LEM domains in 144 proteins in SMART's nrdb database.

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