MIF4G

Middle domain of eukaryotic initiation factor 4G (eIF4G)
MIF4G
SMART accession number:SM00543
Description: Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Interpro abstract (IPR003890):

MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA [(PUBMED:10973054)].

GO function:protein binding (GO:0005515), RNA binding (GO:0003723), DNA binding (GO:0003677)
Family alignment:
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There are 1305 MIF4G domains in 1079 proteins in SMART's nrdb database.

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