MBT

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
MBT
SMART accession number:SM00561
Description: Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.
Interpro abstract (IPR004092):

The function of the malignant brain tumor (MBT) repeat is unknown, but is found in a number of nuclear proteins involved in transcriptional repression. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

The crystal structure of the two MBT repeats of human SCM-like 2 protein has been reported. Each repeat consists of an extended "arm" and a globular core. The arm of the first repeat packs against the core of the second repeat and vice versa. The structure of the core-interacting part of each arm consists of an N-terminal alpha-helix and a turn of 310 helix connected by a short beta-strand. The core consists of an Src homology 3-like five-stranded beta-barrel followed by a C-terminal alpha-helix and another short beta-strand. Each arm interacts with its partner core in a similar way, with the orientation of the N-terminal helix relative to the barrel varying slightly. There are also extensive interactions between the two barrels [(PUBMED:12952983)].

GO process:regulation of transcription, DNA-dependent (GO:0006355)
GO component:nucleus (GO:0005634)
Family alignment:
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There are 1294 MBT domains in 451 proteins in SMART's nrdb database.

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