CHKZnF_C4 abd HLH domain containing kinases domain |
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| SMART accession number: | SM00587
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| Description: |
subfamily of choline kinases |
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| Interpro abstract (IPR015897): |
Zinc finger C4 and HLH domain containing kinases domain subfamily of choline kinases.
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| Family alignment: |
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There are 912
CHK domains in 871 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Cellular role (predicted cellular role)
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Binding / catalysis: kinase
- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Doerks T, Copley RR, Schultz J, Ponting CP, Bork P
- Systematic identification of novel protein domain families associated with nuclear functions.
- Genome Res. 2002; 12: 47-56
- Display abstract
A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a CHK domain in a specific node, click on it.