RUN |
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| SMART accession number: | SM00593
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| Description: |
domain involved in Ras-like GTPase signaling |
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| Interpro abstract (IPR004012): |
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could therefore play important roles in multiple Ras-like GTPase signalling pathways.
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| Family alignment: |
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There are 858
RUN domains in 791 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Burchett SA
- Regulators of G protein signaling: a bestiary of modular protein binding domains.
- J Neurochem. 2000; 75: 1335-51
- Display abstract
Members of the newly discovered regulator of G protein signaling (RGS) families of proteins have a common RGS domain. This RGS domain is necessary for conferring upon RGS proteins the capacity to regulate negatively a variety of Galpha protein subunits. However, RGS proteins are more than simply negative regulators of signaling. RGS proteins can function as effector antagonists, and recent evidence suggests that RGS proteins can have positive effects on signaling as well. Many RGS proteins possess additional C- and N-terminal modular protein-binding domains and motifs. The presence of these additional modules within the RGS proteins provides for multiple novel regulatory interactions performed by these molecules. These regions are involved in conferring regulatory selectivity to specific Galpha-coupled signaling pathways, enhancing the efficacy of the RGS domain, and the translocation or targeting of RGS proteins to intracellular membranes. In other instances, these domains are involved in cross-talk between different Galpha-coupled signaling pathways and, in some cases, likely serve to integrate small GTPases with these G protein signaling pathways. This review discusses these C- and N-terminal domains and their roles in the biology of the brain-enriched RGS proteins. Methods that can be used to investigate the function of these domains are also discussed.
- Structure (3D structures containing this domain)
3D Structures of RUN domains in PDB
| PDB code | Main view | Title | | 2cxf |  | Run domain of rap2 interacting protein x, crystallized in c2 space group |
| 2cxl |  | Run domain of rap2 interacting protein x, crystallized in i422 space group |
| 2dwg |  | Run domain of rap2 interacting protein x, crystallized in p2(1)2(1)2(1) space group |
| 2dwk |  | Crystal structure of the run domain of mouse rap2 interacting protein x |
| 3cwz |  | Strucure of rab6(gtp)-r6ip1 complex |
- Links (links to other resources describing this domain)
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